Current Topics in Microbiology and Immunology

Attempts to Understand Metastasis Formation I

Metastasis-Related Molecules

Editors: Günthert, Ursula, Birchmeier, Walter (Eds.)

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About this book

In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The pu-rpose of these three volumes is to review the recent progress in molecular metas­ tasis research and to attempt to further understand the biol­ ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta­ sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio­ genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno­ logy compile the most recent developments on these meta­ stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex metastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.

Table of contents (16 chapters)

  • Complex Roles of Matrix Metalloproteinases in Tumor Progression

    Powell, W. C. (et al.)

    Pages 1-21

  • Membrane Type-Matrix Metalloproteinase and Tumor Invasion

    Seiki, M.

    Pages 23-30

  • Plasminogen Activators and Angiogenesis

    Mignatti, P. (et al.)

    Pages 33-50

  • Maspin: A Tumor Suppressing Serpin

    Sager, R. (et al.)

    Pages 51-64

  • Different Roles for Plasminogen Activators and Metalloproteinases in Melanoma Metastasis

    Mueller, B. M.

    Pages 65-80

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-61107-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA
  • ISBN 978-3-642-64697-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Attempts to Understand Metastasis Formation I
Book Subtitle
Metastasis-Related Molecules
Editors
  • Ursula Günthert
  • Walter Birchmeier
Series Title
Current Topics in Microbiology and Immunology
Series Volume
213/1
Copyright
1996
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-61107-0
DOI
10.1007/978-3-642-61107-0
Softcover ISBN
978-3-642-64697-3
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XV, 296
Topics