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Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders

  • Conference proceedings
  • © 2003

Overview

Editors:
  1. Dennis J. Selkoe

    1. Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Yves Christen

    1. Pour la Recherche Thérapeutique, Fondation IPSEN, Paris Cedex 16, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (10 papers)

  1. Front Matter

    Pages I-XIV
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  2. Immunologic and Tolerogenic Aspects of Amyloid Beta-Peptide: Implications for the Pathogenesis and Treatment of Alzheimer’s Disease

    • A. Monsonego, H. L. Weiner
    Pages 1-10

  3. Towards Diagnosis and Treatment of Alzheimer’s Disease

    • B. Solomon
    Pages 11-19

  4. Characterization of Amyloid Beta Vaccination Strategies in Mice

    • C. Cao, K. E. Ugen, C. Dickey, D. Wilcock, Y. Bai, M. N. Gordon et al.
    Pages 21-31

  5. Cognitive Characteristics of TgAPP CRND8 Mice Immunised with Beta Amyloid Peptide

    • C. Janus, H.-S. Johnson, J. McLaurin, P. Fraser, P. St. George-Hyslop, D. Westaway
    Pages 33-43

  6. Intranasal Aβ Vaccination as an Approach to Treating β-Amyloidosis

    • D. J. Selkoe
    Pages 45-57

  7. Improvements in Intranasal Amyloid-β (Aβ) Immunization in Mice

    • C. A. Lemere, E. T. Spooner, J. F. Leverone, J. D. Clements
    Pages 59-74

  8. Antibody Therapy Against β-Amyloid to Treat Alzheimer’s Disease

    • F. Bard, P. Seubert, D. Schenk, T. Yednock
    Pages 75-83

  9. Effects of a Peripheral Anti-Aβ Antibody on Plasma and CNS Aβ Clearance

    • D. M. Holtzman, K. R. Bales, S. M. Paul, R. B. DeMattos
    Pages 85-95

  10. Multiphoton Microscopy: Imaging Plaques and Reversal of Plaques — a Transgenic Model by Multiphoton Microscopy

    • B. T. Hyman, B. J. Bacskai
    Pages 97-105

  11. Antibodies as Therapeutic Agents for Prion Disease

    • D. Peretz, R. A. Williamson, K. Kaneko, D. R. Burton, S. B. Prusiner
    Pages 107-123

  12. Back Matter

    Pages 125-126
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Keywords

About this book

Promising effects in mice of immunization by ß-amyloid stimulated substantial research efforts and high hopes. In retrospect, this study appears simultaneously logical, consistent as it is with the amyloid theory central today in the field of Alzheimer's disease studies, and paradoxical, because it involved using the toxic substance itself for a treatment benefit. The research thus begun opens up multiple perspectives for experimentation and for treatment. Clinical trials began, but had to be stopped in January 2002 because of serious side effects. The editors' objective for this book is not to arouse false hopes for a therapeutic project that must still be proven, but to discuss the available information and the questions it raises.

Editors and Affiliations

  • Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, USA

    Dennis J. Selkoe

  • Pour la Recherche Thérapeutique, Fondation IPSEN, Paris Cedex 16, France

    Yves Christen

Bibliographic Information

  • Book Title: Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders

  • Editors: Dennis J. Selkoe, Yves Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-642-59332-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2003

  • Softcover ISBN: 978-3-642-63937-1Published: 18 September 2011

  • eBook ISBN: 978-3-642-59332-1Published: 06 December 2012

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: VIII, 130

  • Number of Illustrations: 11 illustrations in colour

  • Topics: Neurology

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