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Pharmacology of GABA and Glycine Neurotransmission

  • Book
  • © 2001

Overview

Editors:
  1. Hanns Möhler

    1. Institute of Pharmacology and Toxicology, ETH and University of Zürich, Zürich, Switzerland

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 150)

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Table of contents (16 chapters)

  1. Front Matter

    Pages I-XXI
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  2. Physiology of the Neurotransmitters GABA and Glycine

    1. Front Matter

      Pages 1-1
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    2. Physiology of the GABA and Glycine Systems

      • B. E. Alger, F. E. N. Le Beau
      Pages 3-76

  3. Pharmacology of the GABA System

    1. Front Matter

      Pages 77-77
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    2. GABAA Receptors

      1. The Molecular Architecture of GABAA Receptors
        • E. A. Barnard
        Pages 79-99
      2. Functions of GABAA-Receptors: Pharmacology and Pathophysiology
        • H. Möhler
        Pages 101-116
      3. Steroid Modulation of GABAA Receptors
        • J. J. Lambert, J. A. Peters, S. C. Harney, D. Belelli
        Pages 117-140
      4. Allosteric Modulation of GABAA Receptor Function by General Anesthetics and Alcohols
        • M. D. Krasowski, R. A. Harris, N. L. Harrison
        Pages 141-172
      5. Anticonvulsants Acting on the GABA System
        • B. S. Meldrum, P. Whiting
        Pages 173-194
      6. Heterologous Regulation of GABAA Receptors: Protein Phosphorylation
        • T. G. Smart, P. Thomas, N. J. Brandon, S. J. Moss
        Pages 195-225
      7. Tolerance and Dependence to Ligands of the Benzodiazepine Recognition Sites Expressed by GABAA Receptors
        • E. Costa, J. Auta, A. Guidotti
        Pages 227-250
      8. GABAA Receptors and Disease
        • H. Y. Kim, R. W. Olsen
        Pages 251-270
      9. GABAC Receptors: Structure, Function and Pharmacology
        • J. Bormann, A. Feigenspan
        Pages 271-296

    3. GABAB Receptors

      1. Structure of GABAB Receptors
        • B. Bettler, K. Kaupmann
        Pages 299-309
      2. Pharmacology of GABAB Receptors
        • N. G. Bowery
        Pages 311-328
      3. GABAB Receptor Signaling Pathways
        • S. J. Enna
        Pages 329-342

    4. GABA Transporters

      1. Structure and Function of GABA Transporters
        • B. I. Kanner
        Pages 345-354
      2. Pharmacology of GABA Transporters
        • J. E. Clark, W. A. Clark
        Pages 355-372

  4. Pharmacology of the Glycine System

    1. Front Matter

      Pages 373-373
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    2. Structures, Diversity and Pharmacology of Glycine Receptors and Transporters

      • H. Betz, R. J. Harvey, P. Schloss
      Pages 375-401
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Keywords

About this book

Highlighting the current developments and future directions in GABA and glycine research, this volume covers the major inhibitory neurotransmitters from the molecular mechanisms of signal transduction to their role in health and disease. It is of topical importance because these neurotransmitters are essential for brain function and therapy of diseases such as anxiety disorders, insomnias, epilepsy, depression, spasticity, and memory deficits. Distinguished scientists at the forefront of research contributed reviews on the role of these transmitters in governing neuronal networks, their signalling pathways, their receptors, the pharmacology of GABA A- and GABA B- and GABA C-receptors as well as of GABA- and glycine-transporters, and their role in disease. The volume serves as reference for pharmacologists/toxicologists, neuroscientists, neurologists and psychiatrists.

Editors and Affiliations

  • Institute of Pharmacology and Toxicology, ETH and University of Zürich, Zürich, Switzerland

    Hanns Möhler

Bibliographic Information

  • Book Title: Pharmacology of GABA and Glycine Neurotransmission

  • Editors: Hanns Möhler

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-56833-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2001

  • Hardcover ISBN: 978-3-540-67616-4Published: 15 December 2000

  • Softcover ISBN: 978-3-642-63191-7Published: 21 November 2012

  • eBook ISBN: 978-3-642-56833-6Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXI, 413

  • Number of Illustrations: 44 b/w illustrations, 4 illustrations in colour

  • Topics: Pharmacology/Toxicology, Psychopharmacology, Neurology, Neurosciences, Psychiatry, Human Physiology

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