Progress in Molecular and Subcellular Biology

Protein Degradation in Health and Disease

Editors: Reboud-Ravaux, Michele (Ed.)

  • A concise overview of protein degradation, unique in its perspective on both fundamental mechanisms and implications for medical research

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About this book

Protein degradation has been identified as a centerpiece of regulation of cell functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Table of contents (7 chapters)

  • Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth

    Kamura, Takumi (et al.)

    Pages 1-15

  • Aging of Proteins and the Proteasome

    Friguet, Bertrand

    Pages 17-33

  • Protein Degradation in the Aging Organism

    Ward, Walter F.

    Pages 35-42

  • Protein Degradation in Alzheimer’s Disease and Aging of the Brain

    Tsuji, Teruyuki (et al.)

    Pages 43-60

  • Protein Degradation in Human Disease

    Plemper, Richard K. (et al.)

    Pages 61-84

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-642-56373-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $129.00
price for USA
  • ISBN 978-3-642-62714-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Protein Degradation in Health and Disease
Editors
  • Michele Reboud-Ravaux
Series Title
Progress in Molecular and Subcellular Biology
Series Volume
29
Copyright
2002
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-56373-7
DOI
10.1007/978-3-642-56373-7
Softcover ISBN
978-3-642-62714-9
Series ISSN
0079-6484
Edition Number
1
Number of Pages
X, 130
Topics