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Mechanisms of Organ Dysfunction in Critical Illness

  • Book
  • © 2002

Overview

Editors:
  1. Timothy W. Evans

    1. Intensive Care Unit, Royal Brompton Hospital, London, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Mitchell P. Fink

    1. Division of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Update in Intensive Care Medicine (UICMSOFT)

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Table of contents (28 chapters)

  1. Front Matter

    Pages I-XVI
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  2. Mitochondrial Biology

    1. Front Matter

      Pages 1-1
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    2. Cellular Responses to Hypoxia: Role of Oxidant Signal Transduction

      • P. T. Schumacker
      Pages 3-16

    3. The Mitochondrial Permeability Transition: A‘Pore’Way to Die

      • A. P. Halestrap, A. O’Toole, K. Lim
      Pages 17-39

    4. Cytopathic Hypoxia in Circulatory Shock: The Role of Poly (ADP-Ribose) Synthetase Activation

      • C. Szabó
      Pages 40-51

    5. Derangements in Cellular Oxygen Metabolism

      • X. M. Leverve
      Pages 52-68

    6. Pharmacologic and Metabolic Mitochondrial Rescue

      • J. M. Weinberg, M. A. Venkatachalam, I. Nissim
      Pages 69-91

  3. Leukocytes and Cell Signaling Mechanisms in Inflammation

    1. Front Matter

      Pages 93-93
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    2. Role of Leukocytes in Sepsis and Lung Injury

      • W. L. Lee, G. P. Downey
      Pages 95-109

    3. Dysregulated Neutrophil Apoptosis in the Pathogenesis of Organ Injury in Critical Illness

      • J. C. Marshall, S. Hui Jia, R. Taneja
      Pages 110-123

    4. Does Apoptosis Play a Role in the Development of Sepsis-Induced Myocardial Dysfunction?

      • R. Nevière, P. Marchetti
      Pages 124-136

    5. The Intracellular Signaling Pathways of Inflammatory Stress

      • J. Saklatvala, A. Clark, J. Dean
      Pages 137-145

    6. Pro-Inflammatory Cytokines: Double-Edged Swords in the Pathogenesis of Bacterial Infection

      • T. van der Poll
      Pages 146-158

    7. Organ-Organ Interactions in Multiple Organ Failure

      • J. J. Wizorek, T. G. Buchman
      Pages 159-171

  4. Microcirculatory Dysfunction

    1. Front Matter

      Pages 173-173
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    2. Endothelial Cell Dysfunction and Abnormal Tissue Perfusion

      • B. Vallet, E. Wiel, P.-A. Rodie-Talbère
      Pages 175-190

    3. The Microcirculation in Sepsis

      • A. W. Sielenkämper, C. G. Ellis, P. Kvietys
      Pages 191-202

  5. Lung and Kidney

    1. Front Matter

      Pages 203-203
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    2. Pulmonary Vascular Dysfunction

      • S. J. Finney, S. J. Wort, T. W. Evans
      Pages 205-221

    3. Pulmonary Epithelial Injury: Clinical and Experimental Evidence for a Major Role in Acute Lung Injury and Multiple Organ Dysfunction

      • M. A. Matthay, L. B. Ware, J. A. Frank
      Pages 222-226
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Keywords

About this book

The pathophysiology of sepsis can be regarded as a series of steps, beginning with the invasion of normally sterile tissue by microbes and the elaboration of various pro-inflammatory mediators. The final common pathway is often the development of the multiple organ dysfunction syndrome (MODS). Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions. Nevertheless, efforts by both clinical and laboratory scientists are leading to new knowledge in this area. The chapters in this volume provide a state-of-the-art overview of many aspects of the pathophysiology of organ dysfunction in critical illness.

Editors and Affiliations

  • Intensive Care Unit, Royal Brompton Hospital, London, UK

    Timothy W. Evans

  • Division of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA

    Mitchell P. Fink

Bibliographic Information

  • Book Title: Mechanisms of Organ Dysfunction in Critical Illness

  • Editors: Timothy W. Evans, Mitchell P. Fink

  • Series Title: Update in Intensive Care Medicine

  • DOI: https://doi.org/10.1007/978-3-642-56107-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2002

  • Hardcover ISBN: 978-3-540-42193-1Published: 28 August 2001

  • Softcover ISBN: 978-3-540-42692-9Published: 21 January 2002

  • eBook ISBN: 978-3-642-56107-8Published: 06 December 2012

  • Series ISSN: 1610-4056

  • Edition Number: 1

  • Number of Pages: XVI, 410

  • Topics: Intensive / Critical Care Medicine

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