Recent Results in Cancer Research

Small Molecules in Oncology

Editors: Martens, Uwe M. (Ed.)

  • Detailed coverage of the most recent developments in targeted cancer therapy using small molecules
  • Full discussion of preclinical studies, clinical trials, and treatment applications
  • Written by acknowledged experts
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  • ISBN 978-3-642-54490-3
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Hardcover $139.00
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  • ISBN 978-3-642-54489-7
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Softcover $139.00
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  • ISBN 978-3-662-51925-7
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About this book

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Reviews

“The book is recommended for healthcare professionals, scientists, and students in medical and scientific fields. In 25 well-written chapters, experts in their fields of research describe in great detail 12 compounds currently in clinical use for the treatment of hematological malignancies, and 13 compounds applicable to specific mutation-containing malignancies or aimed at interfering with the microenvironment (such as angiogenesis). … This book provides important practical information on a wide variety of novel small molecule-based treatment approaches.” (George Somlo, Doody's Book Reviews, April, 2015)


Table of contents (25 chapters)

  • Imatinib Mesylate

    Waller, Cornelius F.

    Pages 1-25

  • Dasatinib

    Lindauer, Markus (et al.)

    Pages 27-65

  • Nilotinib

    Ostendorf, Benjamin N. (et al.)

    Pages 67-80

  • Bosutinib: A Novel Second-Generation Tyrosine Kinase Inhibitor

    Isfort, Susanne (et al.)

    Pages 81-97

  • Ponatinib: A Third-Generation Inhibitor for the Treatment of CML

    Wehrle, Julius (et al.)

    Pages 99-107

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-54490-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-3-642-54489-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-3-662-51925-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Small Molecules in Oncology
Editors
  • Uwe M. Martens
Series Title
Recent Results in Cancer Research
Series Volume
201
Copyright
2014
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-54490-3
DOI
10.1007/978-3-642-54490-3
Hardcover ISBN
978-3-642-54489-7
Softcover ISBN
978-3-662-51925-7
Series ISSN
0080-0015
Edition Number
2
Number of Pages
XVI, 417
Number of Illustrations and Tables
20 b/w illustrations, 26 illustrations in colour
Topics