Filaggrin

Basic Science, Epidemiology, Clinical Aspects and Management

Editors: Thyssen, Jacob P., Maibach, Howard I. (Eds.)

  • First book to be devoted to the subject
  • Comprehensive overview of the effects of FLG mutations in health and disease
  • Wide appeal to the many different specialties that work with this area
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eBook $59.99
price for USA (gross)
  • ISBN 978-3-642-54379-1
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  • Immediate eBook download after purchase
Hardcover $79.99
price for USA
  • ISBN 978-3-642-54378-4
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $79.99
price for USA
  • ISBN 978-3-662-51117-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
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  • can be used across all devices
About this book

Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.

About the authors

Jacob Thyssen has worked in Dermatology for 10 years and holds PhD and DmSci degrees from the University of Copenhagen. He has published 190 articles and 10 book chapters. He has received international awards for his research, including the LEO Pharma Research Foundation for best investigator <45 years in the Nordic countries. His research has focused on dermatitis, allergies, and the skin barrier. He has been a research fellow in the USA, visiting Harvard Medical School and UCSF. He is a regular speaker at international meetings. Jacob Thyssen enjoys treating patients with dermatitis on a daily basis in the Gentofte Clinic in Copenhagen, Denmark.

Table of contents (36 chapters)

  • Function of Filaggrin and Its Metabolites

    Kezic, Sanja

    Pages 3-8

  • Morphology of Filaggrin-Depleted Epidermis

    Gruber, Robert

    Pages 9-21

  • Stratum Corneum Lipids and Filaggrin

    Jungersted, Jakob Mutanu

    Pages 23-26

  • Inflammatory-Driven Depletion of Filaggrin Proteins

    Vestergaard, Christian (et al.)

    Pages 27-36

  • Immune Activity and Vitamin D

    Bonefeld, Charlotte M. (et al.)

    Pages 37-47

Buy this book

eBook $59.99
price for USA (gross)
  • ISBN 978-3-642-54379-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $79.99
price for USA
  • ISBN 978-3-642-54378-4
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $79.99
price for USA
  • ISBN 978-3-662-51117-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Filaggrin
Book Subtitle
Basic Science, Epidemiology, Clinical Aspects and Management
Editors
  • Jacob P. Thyssen
  • Howard I. Maibach
Copyright
2014
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-54379-1
DOI
10.1007/978-3-642-54379-1
Hardcover ISBN
978-3-642-54378-4
Softcover ISBN
978-3-662-51117-6
Edition Number
1
Number of Pages
XV, 373
Number of Illustrations and Tables
78 b/w illustrations, 82 illustrations in colour
Topics