Springer Series in Biophysics

Membrane Transport Mechanism

3D Structure and Beyond

Editors: Krämer, Reinhard, Ziegler, Christine (Eds.)

  • Covers wide range of different membrane transporters
  • Links 3D structure to function
  • Written by international renowned experts
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  • ISBN 978-3-642-53839-1
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About this book

This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, “a molecular movie”. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics.

Table of contents (11 chapters)

  • Dance Lessons for Proteins: The Dynamics and Thermodynamics of a Sodium/Aspartate Symporter

    Boudker, Olga (et al.)

    Pages 1-22

  • Characterizing the Structure, Function, and Evolution of Human Solute Carrier (SLC) Transporters Using Computational Approaches

    Schlessinger, Avner

    Pages 23-57

  • Structures of the Prokaryotic Galactose Transporter vSGLT and Their Implications on Alternating Access Mechanism in Human SGLT1

    Abramson, Jeff (et al.)

    Pages 59-78

  • Moving Crystallographic Snapshots: A Mechanism for Transport Regulation in BetP

    Ziegler, Christine (et al.)

    Pages 79-98

  • Development of Refined Homology Models: Adding the Missing Information to the Medically Relevant Neurotransmitter Transporters

    Stockner, Thomas (et al.)

    Pages 99-120

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-642-53839-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-642-53838-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-3-662-52305-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Membrane Transport Mechanism
Book Subtitle
3D Structure and Beyond
Editors
  • Reinhard Krämer
  • Christine Ziegler
Series Title
Springer Series in Biophysics
Series Volume
17
Copyright
2014
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-53839-1
DOI
10.1007/978-3-642-53839-1
Hardcover ISBN
978-3-642-53838-4
Softcover ISBN
978-3-662-52305-6
Series ISSN
0932-2353
Edition Number
1
Number of Pages
XII, 272
Number of Illustrations and Tables
9 b/w illustrations, 56 illustrations in colour
Topics