Current Topics in Microbiology and Immunology

Molecular Analysis of DNA Rearrangements in the Immune System

Editors: Jessberger, Rolf, Lieber, Michael R. (Eds.)

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About this book

The vertebrate immune system is distinctive among defense systems of multicellular organisms. In addition to nonspecific immunity, it generates a randomized array of millions of antigen receptors (immunoglobulins and T-cell receptors). A subset of these receptors are critical for binding to invading microbes or biochemicals from them to tag the microbes for elimination. Three site-directed DNA modification processes are critical to this process in vertebrates. V(D)J recombination generates the array of exons that encode the antigen binding pockets. Recent work summarized in this volume describes the dissection of this process at the biochemical level. The mechanism of the reaction is now understood in considerable detail. The proteins that catalyze many steps of the process have now been identified by biochemical and genetic recon­ stitution and by analysis of genetic mutants defective in V(D)J recombination. Class switch recombination is the process by which the variable domain exon of the heavy chain is changed from IgM to IgG, IgA. or IgE. Recent progress is described in the de­ velopment of an extrachromosomal substrate assay system. Molecular genetic analysis of the process in transgenics is defining some of the cis sequence requirements. Biochemical assays for defining enzymatic components are also described. In addition to exciting progress in V(D)J recombination and class switch recombination, one chapter describes recent pro­ gress in somatic hypermutation.

Table of contents (14 chapters)

  • Initiation of V(D)J Recombination in a Cell-Free System by RAG1 and RAG2 Proteins

    Gent, Dik C. (et al.)

    Pages 1-10

  • rag-1 and rag-2: Biochemistry and Protein Interactions

    Schatz, David G. (et al.)

    Pages 11-29

  • Regulation of Recombination Activating Gene Expression During Lymphocyte Development

    Grawunder, Ulf (et al.)

    Pages 31-43

  • The Cell Cycle and V(D)J Recombination

    Desiderio, Stephen (et al.)

    Pages 45-59

  • Double-Strand Breaks, DNA Hairpins, and the Mechanism of V(D)J Recombination

    Bockheim Steen, Sharri (et al.)

    Pages 61-77

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-3-642-50140-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA
  • ISBN 978-3-642-50142-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Analysis of DNA Rearrangements in the Immune System
Editors
  • Rolf Jessberger
  • Michael R. Lieber
Series Title
Current Topics in Microbiology and Immunology
Series Volume
217
Copyright
1996
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-50140-1
DOI
10.1007/978-3-642-50140-1
Softcover ISBN
978-3-642-50142-5
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 224
Topics