Current Topics in Microbiology and Immunology

Genetics of Immunological Diseases

Editors: Mock, Beverly, Potter, Michael (Eds.)

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About this book

The development of innovative molecular techniques such as pulse-field gel electro­ phoresis, cDNA subtraction libraries and chromosome hopping libraries coupled with the increasing popularity in the prospect of sequencing mammalian genomes, has triggered a resurgence of interest in finding and characterizing genes that playa role in modifying immune processes and diseases. Genetically defined strains of mice (e. g. , inbred strains and recently derived stocks of wild mice) provide ideal models for examining the genetic control of diseases as a result of their syntenic relationship with man in genetic composition as well as linkage conserva­ tion. Due to the relative ease of producing a specific genotype via appropriate breeding schedules, murine models may provide the only hope for unravelling those complex disease processes under mUltigenic control. This issue of CTMI is a collection of papers on the characterization and mapping of genes involved in mutations and dysregulated immune responses which produce disease phenotypes. These papers were presented at a workshop which was devoted to examining reverse genetic approaches at localizing, cloning and characterizing genes involved in a variety of developmental, autoimmune, neoplastic and infectious disease processes. In the first of three sections, a series of papers outline the most currently used methods of mapping and isolating genes whose products are unknown. The papers, following, are devoted to specific gene systems whose dysregulation is likely to produce mutant or disease phenotypes.

Table of contents (49 chapters)

  • The Long-Range Mapping of Mammalian Chromosomes

    Brown, S. D. M. (et al.)

    Pages 3-12

  • The Use of Interspecific Mouse Crosses for Gene Localization: Present Status and Future Perspectives

    Guénet, J. L. (et al.)

    Pages 13-17

  • X-Chromosome Gene Order in Different Mus Species Crosses

    Stephenson, D. A. (et al.)

    Pages 18-24

  • Bayesian Multilocus Linkage Mapping

    Blank, R. D. (et al.)

    Pages 25-32

  • The Rat Gene Map

    Szpirer, C. (et al.)

    Pages 33-38

Buy this book

eBook $74.99
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-642-50059-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-642-50061-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Genetics of Immunological Diseases
Editors
  • Beverly Mock
  • Michael Potter
Series Title
Current Topics in Microbiology and Immunology
Series Volume
137
Copyright
1988
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-50059-6
DOI
10.1007/978-3-642-50059-6
Softcover ISBN
978-3-642-50061-9
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XI, 335
Number of Illustrations and Tables
44 b/w illustrations
Topics