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Neuronal Grafting and Alzheimer’s Disease

  • Conference proceedings
  • © 1989

Overview

Editors:
  1. F. H. Gage

    1. Neurosciences, School of Madicine, M. 024 University of California, La Jolla, USA

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  2. A. Privat

    1. Laboratoire de Neurobiologie, Institut de Biologie, Montpellier, France

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  3. Yves Christen

    1. pour la Recherche Therapeutique, Fondation IPSEN, Paris Cedex, France

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Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (17 papers)

  1. Front Matter

    Pages I-XIV
    Download chapter PDF

  2. Neuronal Grafting and Alzheimer’s Disease: Introduction

    • F. H. Gage, A. Privat, Y. Christen
    Pages 1-3

  3. Nigral and Striatal Grafts to the Lesioned Neostriatum: Models of Graft Function

    • A. Björklund, O. Isacson, P. Brundin, S. B. Dunnett
    Pages 4-20

  4. Intracerebral Grafts of Dopaminergic Neurons: A Discussion of Their Functional Effects and Mechanisms of Action

    • J. P. Herman, K. Choulli, N. Abrous, M. Le Moal
    Pages 21-33

  5. Purkinje Cell Replacement by Intracerebellar Neuronal Implants in an Animal Model of Heredodegenerative Ataxia: An Overview

    • C. Sotelo
    Pages 34-42

  6. Spontaneous Remyelination and Intracerebral Grafting of Myelinating Cells in Mammals

    • M. Gumpel, O. Gout, A. Gansmuller
    Pages 43-53

  7. Synaptic Plasticity vs Pathology in Alzheimer’s Disease: Implications for Transplantation

    • C. W. Cotman
    Pages 54-62

  8. Host Immune Responses to Neural Transplantation: A Possible Model for Autoimmune Diseases of the Central Nervous System

    • R. D. Lund, K. Rao, T. J. Gill
    Pages 63-72

  9. NGF in CNS: Sites of Synthesis and Effects of Novel Ways to Administer NGF on Intrinsic Cholinergic Neurons and Grafts of Cholinergic Neurons and Their Target Areas

    • L. Olson, C. Ayer-LeLiévre, T. Ebendal, M. Eriksdotter-Nilsson, P. Ernfors, P. Mouton et al.
    Pages 73-84

  10. Short-Term Memory in Rodent Models of Ageing: Effects of Cortical Cholinergic Grafts

    • S. B. Dunnett
    Pages 85-102

  11. Pathophysiology of the Subcortically Deafferented Hippocampus: Improvement and Deterioration of Function by Fetal Grafts

    • G. Buzsáki, F. H. Gage
    Pages 103-119

  12. Can Fetal Cell Grafts be Expected to Ameliorate Symptoms of Human Neurodegenerative Disorders? Evidence from Animal Models

    • T. J. Collier, J. R. Sladek Jr.
    Pages 120-129

  13. Age-Related Changes in Rat Hippocampal Noradrenergic Transmission: Insights from In Oculo Transplants

    • B. Hoffer, P. Bickford-Wimer, M. Eriksdotter-Nilsson, A.-C. Granholm, M. Palmer, G. Gerhardt et al.
    Pages 130-140

  14. Neural Grafts and Neurotransmitter Interactions in Cognitive Deficits

    • M. Segal, G. Richter-Levin, V. Greenberger, R. Shpiegelman
    Pages 141-149

  15. Serotonin-Expressing Cells from Different Microregions of the Embryonic Rat Rhombencephalon: Behaviour in Cell Culture and in Transplants to the Adult Spinal Cord

    • N. König, N. Rajaofetra, M. J. Drian, F. Favier, F. Sandillon, C. Fuentès et al.
    Pages 150-164

  16. Two Approaches for the Reversal of Phenobarbital-Induced Behavioral Birth Defects

    • J. Yanai, F. Fares, M. Gavish, Z. Greenfeld, C. G. Pick, Y. Rogel-Fuchs et al.
    Pages 165-176

  17. Differential Neural Plasticity of Diffuse Monoaminergic and Point-to-Point Sensory Afferents as Demonstrated by Responses to Target Deprivation and Fetal Neural Transplants

    • M. Peschanski, F. Nothias, I. Dusart, B. Onteniente, M. Geffard, O. Isacson
    Pages 177-188

  18. Deleterious and “Overshoot” Effects of Intracerebral Transplants

    • B. Will, J.-Ch. Cassel, C. Kelche
    Pages 189-198

  19. Back Matter

    Pages 199-201
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Keywords

About this book

Alzheimer's disease is one of the major scientific, medical and social challenges of our time. This book (the third volume of proceedings of the Colloques Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique) is dedicated to neuronal grafting and Alzheimer's disease. The wealth of basic information presented testifies to the progress that has been achieved in intracerebral grafting and to the utility of intracerebral grafting as a tool for the understanding of brain development, adult neuronal plasticity and age-related pathology. An answer to the question, whether neuronal grafting will be useful as a therapy for Alzheimer's disease, must wait for a better understanding of the disease and the identification of animal models that can be used to test potential therapies. Meanwhile, the tool of intracerebral grafting may, in the future, be used to address the pathophysiology of Alzheimer's disease.

Editors and Affiliations

  • Neurosciences, School of Madicine, M. 024 University of California, La Jolla, USA

    F. H. Gage

  • Laboratoire de Neurobiologie, Institut de Biologie, Montpellier, France

    A. Privat

  • pour la Recherche Therapeutique, Fondation IPSEN, Paris Cedex, France

    Yves Christen

Bibliographic Information

  • Book Title: Neuronal Grafting and Alzheimer’s Disease

  • Editors: F. H. Gage, A. Privat, Yves Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-642-48369-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1989

  • Softcover ISBN: 978-3-642-48371-4Published: 09 April 2012

  • eBook ISBN: 978-3-642-48369-1Published: 08 March 2013

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: XIV, 202

  • Number of Illustrations: 54 b/w illustrations

  • Topics: Neurology, Internal Medicine, Neurosciences

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