SpringerBriefs in Molecular Medicine

Cell Aging: Molecular Mechanisms and Implications for Disease

Authors: Behl, Christian, Ziegler, Christine

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  • ISBN 978-3-642-45179-9
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Softcover $49.95
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  • ISBN 978-3-642-45178-2
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About this book

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Reviews

From the reviews:

“It is appropriate for graduate students of the biomedical sciences, as well as scientists new to the field of aging. … This is a good introduction to the field of cell aging. … This book provides a thorough, yet brief, review of cell aging through discussions of various mechanisms of aging and age-related diseases and would be useful for a graduate student symposium or newcomers to the field of cell aging.” (Ellen Mary Andrews, Doody’s Book Reviews, April, 2014)


Table of contents (4 chapters)

  • Aging and Cell Aging: An Introduction

    Behl, Christian (et al.)

    Pages 1-8

  • Cell Cycle: The Life Cycle of a Cell

    Behl, Christian (et al.)

    Pages 9-19

  • Theories and Mechanisms of Aging

    Behl, Christian (et al.)

    Pages 21-97

  • Selected Age-Related Disorders

    Behl, Christian (et al.)

    Pages 99-108

Buy this book

eBook $34.99
price for USA (gross)
  • ISBN 978-3-642-45179-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.95
price for USA
  • ISBN 978-3-642-45178-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cell Aging: Molecular Mechanisms and Implications for Disease
Authors
Series Title
SpringerBriefs in Molecular Medicine
Copyright
2014
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
The Author(s)
eBook ISBN
978-3-642-45179-9
DOI
10.1007/978-3-642-45179-9
Softcover ISBN
978-3-642-45178-2
Series ISSN
2197-7925
Edition Number
1
Number of Pages
IX, 108
Number of Illustrations and Tables
2 b/w illustrations, 32 illustrations in colour
Topics