Handbook of Experimental Pharmacology

Voltage Gated Sodium Channels

Editors: Ruben, Peter (Ed.)

  • Gives unprecedented insight into the structural basis of sodium channel function
  • Explores sodium channels from the perspectives of their biophysical behavior
  • Written by leading experts in the field
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eBook $329.00
price for USA (gross)
  • ISBN 978-3-642-41588-3
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Hardcover $419.00
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  • ISBN 978-3-642-41587-6
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Softcover $419.00
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  • ISBN 978-3-662-51202-9
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About this book

A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Table of contents (13 chapters)

  • Introduction to Sodium Channels

    Peters, Colin H. (et al.)

    Pages 1-6

  • The Voltage Sensor Module in Sodium Channels

    Groome, James R.

    Pages 7-31

  • Slow Inactivation of Na+ Channels

    Silva, Jonathan

    Pages 33-49

  • The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels

    Calhoun, Jeffrey D. (et al.)

    Pages 51-89

  • Altered Sodium Channel Gating as Molecular Basis for Pain: Contribution of Activation, Inactivation, and Resurgent Currents

    Lampert, Angelika (et al.)

    Pages 91-110

Buy this book

eBook $329.00
price for USA (gross)
  • ISBN 978-3-642-41588-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $419.00
price for USA
  • ISBN 978-3-642-41587-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $419.00
price for USA
  • ISBN 978-3-662-51202-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Voltage Gated Sodium Channels
Editors
  • Peter Ruben
Series Title
Handbook of Experimental Pharmacology
Series Volume
221
Copyright
2014
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-41588-3
DOI
10.1007/978-3-642-41588-3
Hardcover ISBN
978-3-642-41587-6
Softcover ISBN
978-3-662-51202-9
Series ISSN
0171-2004
Edition Number
1
Number of Pages
VIII, 295
Number of Illustrations and Tables
22 b/w illustrations, 36 illustrations in colour
Topics