Current Topics in Microbiology and Immunology

Thymic Development and Selection of T Lymphocytes

Editors: Boehm, Thomas, Takahama, Yousuke (Eds.)

  • Written by leading experts in the field
  • Addresses key aspects of the process of thymopoiesis
  • Offers perspectives for understanding immunodeficiency and autoimmune diseases
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eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-40252-4
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase
Hardcover $169.99
price for USA
  • ISBN 978-3-642-40251-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.99
price for USA
  • ISBN 978-3-662-51196-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Table of contents (6 chapters)

  • Development and Function of Cortical Thymic Epithelial Cells

    Takada, Kensuke (et al.)

    Pages 1-17

  • Mechanisms of Thymus Medulla Development and Function

    Anderson, Graham (et al.)

    Pages 19-47

  • Self-Peptides in TCR Repertoire Selection and Peripheral T Cell Function

    Lo, Wan-Lin (et al.)

    Pages 49-67

  • Central Tolerance Induction

    Mouchess, Maria L. (et al.)

    Pages 69-86

  • Trafficking to the Thymus

    Zhang, Shirley L. (et al.)

    Pages 87-111

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-40252-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA
  • ISBN 978-3-642-40251-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.99
price for USA
  • ISBN 978-3-662-51196-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Thymic Development and Selection of T Lymphocytes
Editors
  • Thomas Boehm
  • Yousuke Takahama
Series Title
Current Topics in Microbiology and Immunology
Series Volume
373
Copyright
2014
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-40252-4
DOI
10.1007/978-3-642-40252-4
Hardcover ISBN
978-3-642-40251-7
Softcover ISBN
978-3-662-51196-1
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VII, 132
Number of Illustrations and Tables
2 b/w illustrations, 9 illustrations in colour
Topics