Authors:
Provides concepts for the creation of drug-disease models
Written from the industry perspective
Based on many years of experience
Includes supplementary material: sn.pub/extras
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Table of contents (9 chapters)
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Front Matter
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Back Matter
About this book
The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens?
Written from the industry perspective and based on many years of experience, this book offers:
- Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs
- Guidance for exploration and modification of these programs to enhance the understanding of key principles
- Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature
- A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling.
Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
Authors and Affiliations
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Pharma Research and Early Development (p Translational Research Sciences (TRS), F. Hoffmann-La Roche Ltd, Basel, Switzerland
Ronald Gieschke
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F. Hoffmann-La Roche Ltd, Basel, Switzerland
Daniel Serafin
Bibliographic Information
Book Title: Development of Innovative Drugs via Modeling with MATLAB
Book Subtitle: A Practical Guide
Authors: Ronald Gieschke, Daniel Serafin
DOI: https://doi.org/10.1007/978-3-642-39765-3
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2014
Hardcover ISBN: 978-3-642-39764-6Published: 12 December 2013
Softcover ISBN: 978-3-662-52110-6Published: 27 August 2016
eBook ISBN: 978-3-642-39765-3Published: 27 November 2013
Edition Number: 1
Number of Pages: XV, 399
Number of Illustrations: 80 b/w illustrations, 112 illustrations in colour
Topics: Pharmacology/Toxicology, Pharmaceutical Sciences/Technology, Simulation and Modeling, Computer Appl. in Life Sciences