Immunology of Aging

1. Front Matter

   Pages i-xix

   PDF

2. An Introduction on the Old Age and the Aging of the Immune System

   • Mohamad Bagher Eslami

   Pages 1-2

3. The Immune System, a Marker and Modulator of the Rate of Aging

   • Monica De la Fuente

   Pages 3-23

4. Age-Associated Alterations of Pleiotropic Stem Cell and the Therapeutic Implication of Stem Cell Therapy in Aging

   • Ahmad Massoud

   Pages 25-35

5. A Role for Epigenetic Modulation of the Innate Immune Response During Aging

   • Justin W. Killick, Stuart J. Bennett, Irundika H. K. Dias, Christopher R. Dunston, Helen R. Griffiths

   Pages 37-45

6. Basophil, Eosinophil, and Neutrophil Functions in the Elderly

   • Peter Uciechowski, Lothar Rink

   Pages 47-63

7. Dendritic Cells and Dysregulated Immunity in the Elderly

   • Anshu Agrawal, Sudhir Gupta

   Pages 65-73

8. Natural Killer Cell Immunosenescence and Cancer in the Elderly

   • Beatriz Sánchez-Correa, Carmen Campos, Alejandra Pera, Soledad Sánchez Mateos, Sara Morgado, Raquel Tarazona et al.

   Pages 75-86

9. Pattern Recognition Receptors and Aging

   • Karim H. Shalaby

   Pages 87-143

10. Impact of Aging on T Cell Repertoire and Immunity

    • Marcia A. Blackman, David L. Woodland

    Pages 145-159

11. T Cell-Mediated Immunity in the Immunosenescence Process

    • Pierre Olivier Lang

    Pages 161-176

12. Biological and Phenotypic Alterations of T Cells in Aging

    • Ahmad Massoud, Amir Hossein Massoud

    Pages 177-182

13. T Cells Seen from the Metabolic and Aging Perspective

    • Xavier Camous, Anis Larbi

    Pages 183-200

14. Age-Related Alterations in Regulatory T Cells

    • Amir Hossein Massoud

    Pages 201-206

15. Effects of Aging on B Cells

    • Mohammad Hossein Nicknam, Alireza Rezaiemanesh

    Pages 207-209

16. The Role of MicroRNAs in Immunosenescence Process

    • Seyed Hossein Aalaei-andabili, Alireza Zare-Bidoki, Nima Rezaei

    Pages 211-217

17. Immunogenetics of Aging

    • Ali Akbar Amirzargar

    Pages 219-229

18. Aging Immunity and Infection

    • Mehdi Shekarabi, Fatemeh Asgari

    Pages 231-238

19. Influenza Infection in the Elderly

    • Kasra Moazzami, Janet E. McElhaney, Nima Rezaei

    Pages 239-249

20. Optimizing Response to Vaccination in the Elderly

    • Diana Boraschi, Rino Rappuoli, Giuseppe Del Giudice

    Pages 251-261

The rapidity of scientific progress over the last few years guarantees the utility of this new collection of state-of-the-art reviews on the immunology of aging, which is the result of extensive collaboration of more than sixty of the greatest thinkers and scholars in the field, in cooperation with a number of junior colleagues. The book summarizes current knowledge on the cellular and molecular aspects of the aging immune system and their clinical relevance, providing insights into the effects of the aging process on susceptibilities to those diseases most common among elders. The retrieval strategies used to slow down the decline in the immune system in the elderly are another subject detailed extensively. By providing a broad overview of immunosenescence and its consequences, as well as their potential modulation, this book will fill a gap in a timely manner. It will be of value to all immunologists, whether novice or experienced, as well as geriatricians and epidemiologists.

• Age-associated diseases
• Age-related alteration
• Autoimmunity
• Cellular and molecular aspects
• Immunosenescene
• infectious diseases

“This book provides a review of current knowledge regarding the cellular and molecular aspects of the aging immune system and their clinical relevance. … This book provides a general overview of immunosenescence and its consequences. … those in the fields of immunology and geriatrics will likely find this resource most valuable.” (Mario Rodenas, World Allergy Organization, worldallergy.org, June, 2015)

• Department of Immunology, Tehran University of Medical Sciences School of Medicine, Tehran, Iran

  Ahmad Massoud

• Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

  Nima Rezaei

Nima Rezaei is Associate Researcher in Department of Allergy and Clinical Immunology of Children Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran and Chief Executive of Iranian Primary Immunodeficiency Registry (IPIDR), Executive Manager and member of national scientific committee of First International Congress on Immunodeficiency Disorders, as well as Executive Manager of Iranian Journal of Allergy, Asthma and Immunology. He is also Executive Director of UNESCO Chair in Health Education. He was Chief Editor of more than 10 books; i.e. Immune System and Microorganisms; Diagnosis and Treatment in Patients with Primary Immunodeficiency; Primary Immunodeficiency Disorders in Iran; Atopic Dermatitis; Food Allergy; Guideline of Allergies; Guideline of Asthma and published more than 50 articles in international journals.

Policies and ethics