Handbook of Experimental Pharmacology

Pharmacotherapy of Pulmonary Hypertension

Editors: Humbert, Marc, Evgenov, Oleg V., Stasch, Johannes-Peter (Eds.)

  • Written by leading experts in the field of pulmonary hypertension
  • Broadens your understanding of current, evidence-based pharmacological treatments of various forms of pulmonary hypertension
  • Comprehensive review of most recent developments in this field including new signaling pathways
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eBook $329.00
price for USA (gross)
  • ISBN 978-3-642-38664-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $419.00
price for USA
  • ISBN 978-3-642-38663-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $419.00
price for USA
  • ISBN 978-3-662-52157-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.

Table of contents (22 chapters)

  • Definition and Classification of Pulmonary Hypertension

    Humbert, Marc (et al.)

    Pages 3-29

  • Pulmonary Hypertension: Pathophysiology and Signaling Pathways

    Maron, Bradley A. (et al.)

    Pages 31-58

  • Pulmonary Hypertension: Pathology

    Dorfmüller, Peter

    Pages 59-75

  • Pulmonary Hypertension: Biomarkers

    Rhodes, Christopher J. (et al.)

    Pages 77-103

  • Rodent Models of Group 1 Pulmonary Hypertension

    Ryan, John J. (et al.)

    Pages 105-149

Buy this book

eBook $329.00
price for USA (gross)
  • ISBN 978-3-642-38664-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $419.00
price for USA
  • ISBN 978-3-642-38663-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $419.00
price for USA
  • ISBN 978-3-662-52157-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pharmacotherapy of Pulmonary Hypertension
Editors
  • Marc Humbert
  • Oleg V. Evgenov
  • Johannes-Peter Stasch
Series Title
Handbook of Experimental Pharmacology
Series Volume
218
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-38664-0
DOI
10.1007/978-3-642-38664-0
Hardcover ISBN
978-3-642-38663-3
Softcover ISBN
978-3-662-52157-1
Series ISSN
0171-2004
Edition Number
1
Number of Pages
IX, 576
Number of Illustrations and Tables
10 b/w illustrations, 56 illustrations in colour
Topics