Springer Series in Biophysics

Systems Biology of Metabolic and Signaling Networks

Energy, Mass and Information Transfer

Editors: Aon, Miguel A., Saks, Valdur, Schlattner, Uwe (Eds.)

  • Establishes the basis of a 21st century approach to biological complexity
  • Explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions
  • Broadens your understanding of biological phenomena, emphasizing interconnections and functional interrelationships
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eBook $159.00
price for USA (gross)
  • ISBN 978-3-642-38505-6
  • Digitally watermarked, DRM-free
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-642-38504-9
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  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
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  • ISBN 978-3-662-50835-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response.

Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.

Table of contents (13 chapters)

  • From Physiology, Genomes, Systems, and Self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity

    Aon, M. A. (et al.)

    Pages 3-17

  • Complex Systems Biology of Networks: The Riddle and the Challenge

    Aon, Miguel A.

    Pages 19-35

  • The Control Analysis of Signal Transduction

    Westerhoff, Hans V. (et al.)

    Pages 39-62

  • MicroRNAs and Robustness in Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic, and Genetic

    Demongeot, Jacques (et al.)

    Pages 63-114

  • Dynamics of Mitochondrial Redox and Energy Networks: Insights from an Experimental–Computational Synergy

    Cortassa, Sonia (et al.)

    Pages 115-144

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-642-38505-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-642-38504-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-3-662-50835-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Systems Biology of Metabolic and Signaling Networks
Book Subtitle
Energy, Mass and Information Transfer
Editors
  • Miguel A. Aon
  • Valdur Saks
  • Uwe Schlattner
Series Title
Springer Series in Biophysics
Series Volume
16
Copyright
2014
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-38505-6
DOI
10.1007/978-3-642-38505-6
Hardcover ISBN
978-3-642-38504-9
Softcover ISBN
978-3-662-50835-0
Series ISSN
0932-2353
Edition Number
1
Number of Pages
X, 375
Number of Illustrations and Tables
23 b/w illustrations, 67 illustrations in colour
Topics