Epigenetic Therapy of Cancer

Preclinical Models and Treatment Approaches

Editors: Lübbert, Michael, Jones, Peter A. (Eds.)

  • Devotes detailed attention to the translation of basic research and drug development to clinical applications in the treatment of solid tumors as well as hematologic malignancies and hemoglobinopathy
  • Presents the latest evidence derived from preclinical models regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production
  • Discusses DNA methylation abnormalities in depth
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eBook $149.00
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  • ISBN 978-3-642-38404-2
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Hardcover $189.00
price for USA
  • ISBN 978-3-642-38403-5
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  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
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  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 10, 2016
  • ISBN 978-3-662-51928-8
  • Free shipping for individuals worldwide
Rent the ebook  
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About this book

The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.

Reviews

From the reviews:

“This new book covers the timely topic of epigenetic therapy. … The combination of articles describing the basic science framework of epigenetics and the detailed summaries of clinical trials with epigenetic drugs is attractive for a wide readership, ranging from medical students to scientists who are interested in translational studies to clinicians who work for the direct benefit of cancer patients. … This high-quality book is an excellent overview of the current success and future promise of epigenetic therapy.” (Gerd Pfeifer, Doody’s Book Reviews, May, 2014)

Table of contents (13 chapters)

  • The Fundamental Role of Epigenetic Regulation in Normal and Disturbed Cell Growth, Differentiation, and Stemness

    Rodríguez-Paredes, Manuel (et al.)

    Pages 1-41

  • Mouse Models to Study DNA Methylation in Cancer Research

    Savelyeva, Irina (et al.)

    Pages 43-66

  • Epigenetic Regulation of Normal Hematopoietic Development

    Chaurasia, Pratima (et al.)

    Pages 67-87

  • Epigenetic Regulation of Globin Genes and Disturbances in Hemoglobinopathies

    Saunthararajah, Yogen (et al.)

    Pages 89-106

  • DNA Methylation Abnormalities in Hematopoietic Disorders: Biological Significance and Methodological Approaches

    Claus, Rainer (et al.)

    Pages 107-120

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-642-38404-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-642-38403-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 10, 2016
  • ISBN 978-3-662-51928-8
  • Free shipping for individuals worldwide
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Epigenetic Therapy of Cancer
Book Subtitle
Preclinical Models and Treatment Approaches
Editors
  • Michael Lübbert
  • Peter A. Jones
Copyright
2014
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-38404-2
DOI
10.1007/978-3-642-38404-2
Hardcover ISBN
978-3-642-38403-5
Softcover ISBN
978-3-662-51928-8
Edition Number
1
Number of Pages
X, 325
Number of Illustrations and Tables
34 b/w illustrations, 14 illustrations in colour
Topics