Disruption of Protein-Protein Interfaces

In Search of New Inhibitors

Editors: Mangani, Stefano (Ed.)

  • Provides an overview of the present state and future perspectives of drug discovery at protein-protein interfaces
  • Gives details of both computational and experimental tools used in the field
  • Gives positive examples of drug-like molecules effective in interacting at protein-protein interfaces
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eBook $99.00
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  • ISBN 978-3-642-37999-4
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Hardcover $129.99
price for USA
  • ISBN 978-3-642-37998-7
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  • Usually dispatched within 3 to 5 business days.
Softcover $109.99
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  • ISBN 978-3-642-43389-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.

About the authors

Stefano Mangani has been professor of general and inorganic chemistry at the University of Siena since 1994. His main field of research is bioinorganic chemistry and structural biology and he currently focuses on the role of metal ions in metalloenzyme catalysis and in metalloproteins, with particular emphasis on the chemistry occurring at the metal sites as revealed by accurate structural data. Professor Mangani is regularly invited to speak at international conferences and seminars. He is the author of over 140 publications in international scientific journals and book series and has also written a general and inorganic university textbook and a web-course on general chemistry.

Table of contents (6 chapters)

  • Drug Discovery by Targeting Protein–Protein Interactions

    Bettinetti, Laura (et al.)

    Pages 1-29

  • Protein–Protein Interaction Inhibitors: Case Studies on Small Molecules and Natural Compounds

    Ferrari, Stefania (et al.)

    Pages 31-60

  • Disrupting Protein–Protein Interfaces Using GRID Molecular Interaction Fields

    Cross, Simon (et al.)

    Pages 61-82

  • NMR as a Tool to Target Protein–Protein Interactions

    Del Conte, Rebecca (et al.)

    Pages 83-111

  • Protein–Protein Interactions in the Solid State: The Troubles of Crystallizing Protein–Protein Complexes

    Mangani, Stefano

    Pages 113-134

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-642-37999-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.99
price for USA
  • ISBN 978-3-642-37998-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $109.99
price for USA
  • ISBN 978-3-642-43389-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Disruption of Protein-Protein Interfaces
Book Subtitle
In Search of New Inhibitors
Editors
  • Stefano Mangani
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-37999-4
DOI
10.1007/978-3-642-37999-4
Hardcover ISBN
978-3-642-37998-7
Softcover ISBN
978-3-642-43389-4
Edition Number
1
Number of Pages
VII, 161
Topics