Skip to main content
Book cover

Disruption of Protein-Protein Interfaces

In Search of New Inhibitors

  • Book
  • © 2013

Overview

  • Provides an overview of the present state and future perspectives of drug discovery at protein-protein interfaces

  • Gives details of both computational and experimental tools used in the field

  • Gives positive examples of drug-like molecules effective in interacting at protein-protein interfaces

  • Includes supplementary material: sn.pub/extras

This is a preview of subscription content, log in via an institution to check access.

Access this book

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (6 chapters)

Keywords

About this book

"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.

Editors and Affiliations

  • , Department of Biotechnology, Chemistry a, University of Siena, Siena, Italy

    Stefano Mangani

About the editor

Stefano Mangani has been professor of general and inorganic chemistry at the University of Siena since 1994. His main field of research is bioinorganic chemistry and structural biology and he currently focuses on the role of metal ions in metalloenzyme catalysis and in metalloproteins, with particular emphasis on the chemistry occurring at the metal sites as revealed by accurate structural data. Professor Mangani is regularly invited to speak at international conferences and seminars. He is the author of over 140 publications in international scientific journals and book series and has also written a general and inorganic university textbook and a web-course on general chemistry.

Bibliographic Information

  • Book Title: Disruption of Protein-Protein Interfaces

  • Book Subtitle: In Search of New Inhibitors

  • Editors: Stefano Mangani

  • DOI: https://doi.org/10.1007/978-3-642-37999-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2013

  • Hardcover ISBN: 978-3-642-37998-7Published: 09 July 2013

  • Softcover ISBN: 978-3-642-43389-4Published: 04 August 2015

  • eBook ISBN: 978-3-642-37999-4Published: 28 June 2013

  • Edition Number: 1

  • Number of Pages: VII, 161

  • Topics: Organic Chemistry

Publish with us