Current Topics in Microbiology and Immunology

Intrinsic Immunity

Editors: Cullen, Bryan R. (Ed.)

  • Written by leading experts in the field
  • Provides a better understanding of the co-evolution of viral pathogens and their hosts
  • Offers perspectives for the design of antiviral drugs
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  • ISBN 978-3-642-37765-5
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Softcover $219.00
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  • ISBN 978-3-642-42763-3
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About this book

Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.

 

Table of contents (9 chapters)

  • The APOBEC3 Family of Retroelement Restriction Factors

    Refsland, Eric W. (et al.)

    Pages 1-27

  • Inhibition of Retroviral Replication by Members of the TRIM Protein Family

    Fletcher, Adam J. (et al.)

    Pages 29-66

  • The Antiviral Activities of Tetherin

    Neil, Stuart J. D.

    Pages 67-104

  • Restriction of Retroviral Infection of Macrophages

    Sharkey, Mark

    Pages 105-122

  • Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors

    Johnson, Welkin E.

    Pages 123-151

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-3-642-37765-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-3-642-37764-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-3-642-42763-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Intrinsic Immunity
Editors
  • Bryan R. Cullen
Series Title
Current Topics in Microbiology and Immunology
Series Volume
371
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-37765-5
DOI
10.1007/978-3-642-37765-5
Hardcover ISBN
978-3-642-37764-8
Softcover ISBN
978-3-642-42763-3
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VII, 262
Topics