Epigenetics and Human Health

Environmental Epigenomics in Health and Disease

Epigenetics and Complex Diseases

Editors: Jirtle, Randy L., Tyson, Frederick L. (Eds.)

  • Discusses the correlation between environmental influences and brain development, neurological disorders, obesity and cancer
  • Reviews epigenetic processes that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain, discussing autism, schizophrenia and even sexual dimorphism in the developing brains of males and females
  • Includes a chapter on legal and ethical implications of epigenetics​  
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eBook $159.00
price for USA (gross)
  • ISBN 978-3-642-36827-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-3-642-36826-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover n/a
  • ISBN 978-3-642-43595-9
  • Free shipping for individuals worldwide
About this book

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this two volume book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. Consequently, epigenetic research promises to markedly improve our ability to diagnosis, prevent, and treat the pathological conditions of humans; however, it also introduces unique legal and ethical issues. This volume highlights the correlation between environmental factors and complex diseases, such as autism, addiction, neurological diseases, diabetes, obesity and cancer. It concludes with a chapter on legal and ethical implications of epigenetics. ​

Table of contents (14 chapters)

  • Epigenetics and Maternal Brain Evolution

    Keverne, Eric B.

    Pages 3-20

  • Social Environment and DNA Methylation: A Mechanism for Linking Nurture and Nature

    Szyf, Moshe

    Pages 21-35

  • Sex Differences in Epigenetic Programming of Brain Differentiation: Implications for Mental Health and Disease

    Auger, Anthony P. (et al.)

    Pages 37-54

  • Phenotypic Plasticity, Pleiotropy, and the Growth-First Theory of Imprinting

    Wilkins, Jon F.

    Pages 57-72

  • The Imprinted Brain: How Genes Set the Balance Between Autism and Psychosis

    Badcock, Christopher

    Pages 73-96

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-642-36827-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-3-642-36826-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover n/a
  • ISBN 978-3-642-43595-9
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Environmental Epigenomics in Health and Disease
Book Subtitle
Epigenetics and Complex Diseases
Editors
  • Randy L. Jirtle
  • Frederick L. Tyson
Series Title
Epigenetics and Human Health
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-36827-1
DOI
10.1007/978-3-642-36827-1
Hardcover ISBN
978-3-642-36826-4
Softcover ISBN
978-3-642-43595-9
Series ISSN
2191-2262
Edition Number
1
Number of Pages
XIV, 339
Topics