Research and Perspectives in Neurosciences

Programmed Cells from Basic Neuroscience to Therapy

Editors: Gage, Fred H., Christen, Yves (Eds.)

  • Presents latest research on neurodegenerative diseases
  • Presents prospects for novel therapies
  • Written by leading experts in the field ​
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eBook $119.00
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  • ISBN 978-3-642-36648-2
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Hardcover $159.00
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  • ISBN 978-3-642-36647-5
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Softcover $159.00
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  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: September 22, 2016
  • ISBN 978-3-662-51294-4
  • Free shipping for individuals worldwide
About this book

The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases. Among these issues are the variability in PSC generation methods, variability between individuals, epigenetic/genetic instability and the ability to obtain disease-relevant subtypes of neurons . Current protocols for differentiating PSC into specific subtypes of neurons are under development, but more and better protocols are needed. Understanding the molecular pathways involved in human neural differentiation will facilitate the development of methods and tools to enrich and monitor the generation of specific subtypes of neurons that would be more relevant in modeling different neurological diseases.

Table of contents (11 chapters)

  • iPS Cell Technology and Disease Research: Issues To Be Resolved

    Jaenisch, Rudolf

    Pages 1-7

  • Therapeutic Somatic Cell Reprogramming by Nuclear Transfer

    Wang, Stan (et al.)

    Pages 9-15

  • Induction of Neural Lineages from Mesoderm and Endoderm by Defined Transcription Factors

    Wernig, Marius

    Pages 17-30

  • Proposing a Model for Studying Primate Development Using Induced Pluripotent Stem Cells

    Marchetto, Maria C. N. (et al.)

    Pages 31-39

  • HTT Evolution and Brain Development

    Zuccato, Chiara (et al.)

    Pages 41-55

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-3-642-36648-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-3-642-36647-5
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $159.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: September 22, 2016
  • ISBN 978-3-662-51294-4
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Programmed Cells from Basic Neuroscience to Therapy
Editors
  • Fred H. Gage
  • Yves Christen
Series Title
Research and Perspectives in Neurosciences
Series Volume
20
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-36648-2
DOI
10.1007/978-3-642-36648-2
Hardcover ISBN
978-3-642-36647-5
Softcover ISBN
978-3-662-51294-4
Series ISSN
0945-6082
Edition Number
1
Number of Pages
XII, 130
Number of Illustrations and Tables
1 b/w illustrations, 13 illustrations in colour
Topics