Research and Perspectives in Alzheimer's Disease

Proteopathic Seeds and Neurodegenerative Diseases

Editors: Jucker, Mathias, Christen, Yves (Eds.)

  • With contributions from nobel laureats Eric Kandel and Stanley Prusiner
  • Latest research on prion diseases
  • Presents developing therapies ​
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Hardcover $219.00
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Softcover $219.00
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About this book

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer´s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ​

Reviews

“This is a current comprehensive text of the biochemical mechanisms of gene and protein expression encountered in Alzheimer’s, Parkinson’s, ALS, MS, prion disorders, and other degenerative diseases. … Neurologists, neurophysiologists, biochemists, graduate students, postdocs, and anyone in drug development will find it very useful in their work.” (Joseph J. Grenier, Amazon.com, January, 2016)


Table of contents (11 chapters)

  • Widening Spectrum of Prions Causing Neurodegenerative Diseases

    Prusiner, Stanley B.

    Pages 1-17

  • β-Amyloid Fibril Structures, In Vitro and In Vivo

    Tycko, Robert

    Pages 19-31

  • Structure-Activity Relationship of Amyloids

    Greenwald, Jason (et al.)

    Pages 33-46

  • Seeding and Cross-seeding in Amyloid Diseases

    Westermark, Per (et al.)

    Pages 47-60

  • The Prion-Like Aspect of Alzheimer Pathology

    Fritschi, Sarah K. (et al.)

    Pages 61-69

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-3-642-35491-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-3-642-35490-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-3-642-44696-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteopathic Seeds and Neurodegenerative Diseases
Editors
  • Mathias Jucker
  • Yves Christen
Series Title
Research and Perspectives in Alzheimer's Disease
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-35491-5
DOI
10.1007/978-3-642-35491-5
Hardcover ISBN
978-3-642-35490-8
Softcover ISBN
978-3-642-44696-2
Series ISSN
0945-6066
Edition Number
1
Number of Pages
XII, 156
Topics