Sungkyunkwan University Outstanding Research

Sialo-Xenoantigenic Glycobiology

Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation

Authors: Song, Kwon-Ho, Kim, Cheorl-Ho

  • Latest research on Sialo-Xenoantigenic Glycobiology
  • Focuses on carbohydrate antigens including sialic acids as xenoantigenic determinant in human
  • Written by leading experts in the fiel
see more benefits

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-34094-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.00
price for USA
  • ISBN 978-3-642-34093-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.00
price for USA
  • ISBN 978-3-642-43443-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
About this book

Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.

 

Table of contents (5 chapters)

  • Screening of Pig Glycosyltransferase Genes Related to Xenoantigens and Their Masking

    Song, Kwon-Ho (et al.)

    Pages 1-10

  • Cloning and Tissue Specific Expression of pcmah and Its Alternative Transcripts

    Song, Kwon-Ho (et al.)

    Pages 11-18

  • Functional Characterization of pCMAH in the Synthesis of N-Glycolylneuraminic Acid as the Xenoantigenic Determinant in Pig-to-Human Xenotransplantation

    Song, Kwon-Ho (et al.)

    Pages 19-26

  • Identification of Two Alternative Promoters of the Pig CMP-N-Acetylneuraminic Acid Hydroxylase Gene

    Song, Kwon-Ho (et al.)

    Pages 27-42

  • Screening for Xenoantigenic Determinants Formed by Sialyltransferases

    Song, Kwon-Ho (et al.)

    Pages 43-56

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-34094-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.00
price for USA
  • ISBN 978-3-642-34093-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.00
price for USA
  • ISBN 978-3-642-43443-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Sialo-Xenoantigenic Glycobiology
Book Subtitle
Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation
Authors
Series Title
Sungkyunkwan University Outstanding Research
Series Volume
1
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-34094-9
DOI
10.1007/978-3-642-34094-9
Hardcover ISBN
978-3-642-34093-2
Softcover ISBN
978-3-642-43443-3
Series ISSN
2195-3546
Edition Number
1
Number of Pages
XVI, 64
Topics