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Botulinum Neurotoxins

  • Book
  • © 2013

Overview

Editors:
  1. Andreas Rummel

    1. , Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany

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  2. Thomas Binz

    1. , Institut für Physiologische Chemie, Medizinische Hochschule Hannover, Hannover, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Written by leading experts in the field botulinum neurotoxins
  • Provides the current status of basic botulinum neurotoxin research
  • Provides in depth articles on neurotoxins for further medical applications by means of recombinant technologies
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 364)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. Genetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes

    • Karen K. Hill, Theresa J. Smith
    Pages 1-20

  3. Assembly and Function of the Botulinum Neurotoxin Progenitor Complex

    • Shenyan Gu, Rongsheng Jin
    Pages 21-44

  4. Uptake of Botulinum Neurotoxin in the Intestine

    • Yukako Fujinaga, Yo Sugawara, Takuhiro Matsumura
    Pages 45-59

  5. Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity

    • Andreas Rummel
    Pages 61-90

  6. The Elusive Compass of Clostridial Neurotoxins: Deciding When and Where to Go?

    • Kinga Bercsenyi, Francesco Giribaldi, Giampietro Schiavo
    Pages 91-113

  7. Synchronized Chaperone Function of Botulinum Neurotoxin Domains Mediates Light Chain Translocation into Neurons

    • Audrey Fischer
    Pages 115-137

  8. Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmission

    • Thomas Binz
    Pages 139-157

  9. Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins

    • Gudrun Ahnert-Hilger, Agnieszka Münster-Wandowski, Markus Höltje
    Pages 159-177

  10. Persistence of Botulinum Neurotoxin Inactivation of Nerve Function

    • Charles B. Shoemaker, George A. Oyler
    Pages 179-196

  11. Structure-Based Drug Discovery for Botulinum Neurotoxins

    • Subramanyam Swaminathan
    Pages 197-218

  12. Complexity of Botulinum Neurotoxins: Challenges for Detection Technology

    • Martin B. Dorner, K. Melanie Schulz, Skadi Kull, Brigitte G. Dorner
    Pages 219-255

  13. Progress in Cell Based Assays for Botulinum Neurotoxin Detection

    • Sabine Pellett
    Pages 257-285

  14. Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics

    • John Chaddock
    Pages 287-306

  15. Botulinum Toxin: Application, Safety, and Limitations

    • Hans Bigalke
    Pages 307-317

  16. Back Matter

    Pages 319-321
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Keywords

About this book

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Editors and Affiliations

  • , Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany

    Andreas Rummel

  • , Institut für Physiologische Chemie, Medizinische Hochschule Hannover, Hannover, Germany

    Thomas Binz

Bibliographic Information

  • Book Title: Botulinum Neurotoxins

  • Editors: Andreas Rummel, Thomas Binz

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-33570-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2013

  • Hardcover ISBN: 978-3-642-33569-3Published: 14 December 2012

  • Softcover ISBN: 978-3-642-44889-8Published: 29 January 2015

  • eBook ISBN: 978-3-642-33570-9Published: 14 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VIII, 324

  • Topics: Pharmacology/Toxicology, Neurosciences

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