Prokaryotic Toxin-Antitoxins

Editors: Gerdes, Kenn (Ed.)

  • Prokaryotic Toxin-Antitoxins gives a brief and clear overview of a complex and rapidly expanding research field of scientific, biotechnological and medical importance  
  • Written by experts
  • With numerous colour illustrations ​
see more benefits

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-3-642-33253-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-3-642-33252-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-3-642-44657-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Prokaryotic Toxins – Antitoxins gives the first overview of an exciting and rapidly expanding research field. Toxin – antitoxin (TA) genes were discovered on plasmids 30 years ago. Since then it has become evident that TA genes are highly abundant in bacterial and archaeal chromosomes. TA genes code for an antitoxin that combine with and neutralize a cognate toxin. When activated, the toxins inhibit protein synthesis and cell growth and thereby induce dormancy and multidrug tolerance (persistence). Remarkably, in some species, the TA gene families have undergone dramatic expansions. For example, the highly persistent major human pathogen Mycobacterium tuberculosis has »100 TA loci. The large expansion of TA genes by some organisms is a biological mystery. However, recent observations indicate that TA genes contribute cumulatively to the persistence of bacteria. This medically important phenomenon may thus for the first time become experimentally tractable at the molecular level.

Table of contents (19 chapters)

  • Introduction

    Gerdes, Kenn

    Pages 1-8

  • Type I Toxin-Antitoxin Loci: hok/sok and fst

    Weaver, Keith

    Pages 9-26

  • Novel Type I Toxin-Antitoxins Loci

    Fozo, Elizabeth

    Pages 27-43

  • Type II Toxin-Antitoxin Loci: The ccdAB and parDE Families

    Deghorain, Marie (et al.)

    Pages 45-67

  • Type II Toxin-Antitoxins Loci: The relBE Family

    Gerdes, Kenn

    Pages 69-92

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-3-642-33253-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-3-642-33252-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-3-642-44657-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Prokaryotic Toxin-Antitoxins
Editors
  • Kenn Gerdes
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-33253-1
DOI
10.1007/978-3-642-33253-1
Hardcover ISBN
978-3-642-33252-4
Softcover ISBN
978-3-642-44657-3
Edition Number
1
Number of Pages
VIII, 368
Topics