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  • Book
  • © 2013

Systems Biology

  • This volume will be of great interest to investigators already engaged in systems biology research as well as to those scientists and clinicians who may be seeking an introduction to the field.
  • By assembling a diverse spectrum of perspectives and expertise, it is hoped that the information provided will serve as a catalyst for additional innovative approaches.
  • Written by leading experts in this interdisciplinary approach combining talents of biologists, mathematicians and computer scientists.
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 363)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xx
  2. Systems Approaches to Dissecting Immunity

    • Alan Diercks, Alan Aderem
    Pages 1-19
  3. Studying Salmonellae and Yersiniae Host–Pathogen Interactions Using Integrated ‘Omics and Modeling

    • Charles Ansong, Brooke L. Deatherage, Daniel Hyduke, Brian Schmidt, Jason E. McDermott, Marcus B. Jones et al.
    Pages 21-41
  4. ChIP-Seq and the Complexity of Bacterial Transcriptional Regulation

    • James Galagan, Anna Lyubetskaya, Antonio Gomes
    Pages 43-68
  5. ‘Omics Investigations of HIV and SIV Pathogenesis and Innate Immunity

    • Robert E. Palermo, Deborah H. Fuller
    Pages 87-116
  6. Systems Biology of Vaccination in the Elderly

    • Sai S. Duraisingham, Nadine Rouphael, Mary M. Cavanagh, Helder I. Nakaya, Jorg J. Goronzy, Bali Pulendran
    Pages 117-142
  7. Systems Biology Analyses to Define Host Responses to HCV Infection and Therapy

    • Reneé C. Ireton, Michael Gale Jr.
    Pages 143-167
  8. Systems Biology Approach for New Target and Biomarker Identification

    • I-Ming Wang, David J. Stone, David Nickle, Andrey Loboda, Oscar Puig, Christopher Roberts
    Pages 169-199
  9. Insights into Proteomic Immune Cell Signaling and Communication via Data-Driven Modeling

    • Kelly F. Benedict, Douglas A. Lauffenburger
    Pages 201-233
  10. Critical Dynamics in Host–Pathogen Systems

    • Arndt G. Benecke
    Pages 235-259
  11. Back Matter

    Pages 261-263

About this book

First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies—oligonucleotide microarrays, mass spectrometry, and next-generation sequencing—and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology.

Editors and Affiliations

  • , Department of Microbiology, University of Washington at Seattle, Seattle, USA

    Michael G. Katze

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access