Neurofibromatosis Type 1

Molecular and Cellular Biology

Editors: Upadhyaya, Meena, Cooper, David (Eds.)

  • Represents the most comprehensive and up to date account of this common neuroectodermal disorder
  • An outstanding panel of scientists and clinicians covering all aspects of NF1 biology
  • Lessons learned  from the molecular biology of NF1 tumorigenesis can be extrapolated to many other cancers
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Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-3-642-32864-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-3-642-32863-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome.

Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.

Table of contents (44 chapters)

  • von Recklinghausen Disease: 130 Years

    Riccardi, Vincent M.

    Pages 1-16

  • Clinical Diagnosis and Atypical Forms of NF1

    Peltonen, Sirkku (et al.)

    Pages 17-30

  • Management and Treatment of “Complex Neurofibromatosis 1”

    Ferner, Rosalie E. (et al.)

    Pages 31-45

  • Mortality in Neurofibromatosis 1

    Evans, Gareth R.

    Pages 47-54

  • The Cognitive Profile of NF1 Children: Therapeutic Implications

    Pride, Natalie A. (et al.)

    Pages 55-69

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-3-642-32864-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-3-642-32863-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Neurofibromatosis Type 1
Book Subtitle
Molecular and Cellular Biology
Editors
  • Meena Upadhyaya
  • David Cooper
Copyright
2012
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-32864-0
DOI
10.1007/978-3-642-32864-0
Hardcover ISBN
978-3-642-32863-3
Edition Number
1
Number of Pages
XVI, 717
Topics