Studies in Mechanobiology, Tissue Engineering and Biomaterials

Computational Modeling in Tissue Engineering

Editors: Geris, Liesbet (Ed.)

  • Applies the principles of engineering and life sciences toward the development of biological substitutes
  • Helps quantifying and optimizing micro-environmental signals to which cells and tissues are exposed
  • Covers multiple applications from the heart and liver to cartilage and bones
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About this book

One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.

Table of contents (16 chapters)

  • In Vivo, In Vitro, In Silico: Computational Tools for Product and Process Design in Tissue Engineering

    Geris, Liesbet

    Pages 1-15

  • Protein Modelling and Surface Folding by Limiting the Degrees of Freedom

    Israelowitz, Meir (et al.)

    Pages 19-45

  • Adaptive Quasi-Linear Viscoelastic Modeling

    Nekouzadeh, Ali (et al.)

    Pages 47-83

  • Computational Modeling of Mass Transport and Its Relation to Cell Behavior in Tissue Engineering Constructs

    Lambrechts, Dennis (et al.)

    Pages 85-105

  • Computational Methods in the Modeling of Scaffolds for Tissue Engineering

    Olivares, Andy L. (et al.)

    Pages 107-126

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-3-642-32563-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-3-642-32562-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • ISBN 978-3-642-43078-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Computational Modeling in Tissue Engineering
Editors
  • Liesbet Geris
Series Title
Studies in Mechanobiology, Tissue Engineering and Biomaterials
Series Volume
10
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-32563-2
DOI
10.1007/978-3-642-32563-2
Hardcover ISBN
978-3-642-32562-5
Softcover ISBN
978-3-642-43078-7
Series ISSN
1868-2006
Edition Number
1
Number of Pages
XII, 444
Topics