Springer Series on Biofilms

Culture Negative Orthopedic Biofilm Infections

Editors: Ehrlich, G.D., DeMeo, P.J., Costerton, J.W., Winkler, H. (Eds.)

  • Introduces the best diagnostic technologies that modern microbiology can provide
  • Two of the editors (Ehrlich and Costerton) are involved in the development of an automated DNA-based system for the identification of bacteria and fungi in clinical specimens, by Abbott Healthcare
  • Constitutes a cogent statement of the reasons for the replacement of traditional culture methods, with DNA-based systems, in all medical specialities
  • Definitive source of the concepts and the preliminary data on which this huge paradigm shift will be based
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eBook $169.00
price for USA (gross)
  • ISBN 978-3-642-29554-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-3-642-29553-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-3-642-44683-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

During the recent transition between acute diseases caused by swarms of single planktonic bacteria, and chronic infections caused by bacteria growing in slime-enclosed biofilms, a general clinical consensus has emerged that pathologies with bacterial etiologies are frequently culture negative. Because biofilm infections now affect 17 million Americans per year (killing approximately 450,000), the suggestion that these common and lethal infections regularly go unnoticed by the only FDA-approved method for their detection and characterization is a matter of urgent concern. Biologically, we would expect that planktonic bacterial cells would colonize any new surface, including the surface of an agar plate, while the specialized sessile cells of a biofilm community would have no such proclivity. In the study of biofilm diseases ranging from otitis media to prostatitis, it was found that direct microscopy and DNA- and RNA-based molecular methods regularly document the presence of living bacteria in tissues and samples that are culture negative. The editors selected orthopedic biofilm infections as the subject of this book because these infections occur against a background of microbiological sterility in which modern molecular methods would be expected to find bacterial DNA, RNA-based microscopic methods would be expected to locate bacterial cells, and cultures would be negative. Moreover, in Orthopedics we find an already biofilm-adapted surgical group in which current strategies are based on the meticulous removal of compromised tissues, antibiotic options as based on high biofilm-killing local doses, and there are practical bedside strategies for dealing with biofilm infections. So here is where the new paradigm of biofilm infection meets the equally new paradigm of the culture negativity of biofilms, and this volume presents a conceptual synthesis that may soon combine the most effective molecular methods for the detection and identification of bacteria with a surgical discipline that is ready to help patients.

Table of contents (10 chapters)

  • The Problem of Culture-Negative Infections

    Ehrlich, G. D. (et al.)

    Pages 1-15

  • Culture-Negative Infections in Orthopedic Surgery

    Ehrlich, G. D. (et al.)

    Pages 17-27

  • Improved Diagnosis of Biofilm Infections Using Various Molecular Methods

    Thomsen, Trine Rolighed (et al.)

    Pages 29-41

  • Improved Outcomes Via Integrated Molecular Diagnostics and Biofilm Targeted Therapeutics

    Kennedy, John P. (et al.)

    Pages 43-60

  • Immunological Methods for Staphylococcus aureus Infection Diagnosis and Prevention

    Archer, Nathan K. (et al.)

    Pages 61-75

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-3-642-29554-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-3-642-29553-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-3-642-44683-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Culture Negative Orthopedic Biofilm Infections
Editors
  • Garth D. Ehrlich
  • Patrick J. DeMeo
  • J. William Costerton
  • Heinz Winkler
Series Title
Springer Series on Biofilms
Series Volume
7
Copyright
2012
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-29554-6
DOI
10.1007/978-3-642-29554-6
Hardcover ISBN
978-3-642-29553-9
Softcover ISBN
978-3-642-44683-2
Series ISSN
1863-9607
Edition Number
1
Number of Pages
X, 146
Topics