Handbook of Experimental Pharmacology

Antibiotic Resistance

Editors: Coates, Anthony R.M. (Ed.)

  • This book provides views about antibiotic resistance from world experts in the field
  • The book has constructive ways in which to combat resistance,such as combinations of antibiotics, and targeting non-multiplying bacteria
  • It provides an outline of the challenges of the future, namely the need for a rebirth of the golden age of antibiotics in the mid-20th Century when 20 new classes of antibiotics reached the market
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  • ISBN 978-3-642-28951-4
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Hardcover $489.00
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Softcover $489.00
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  • ISBN 978-3-642-43249-1
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About this book

This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.

Table of contents (11 chapters)

  • Introduction to Antibiotic Resistance

    Bax, Richard (et al.)

    Pages 1-12

  • The Origins of Antibiotic Resistance

    Wright, Gerard D.

    Pages 13-30

  • Surveillance Programmes and Antibiotic Resistance: Worldwide and Regional Monitoring of Antibiotic Resistance Trends

    Hawser, Stephen

    Pages 31-43

  • Current and Future Challenges in the Development of Antimicrobial Agents

    Rennie, Robert P.

    Pages 45-65

  • The Role of the Outer Membrane of Gram-negative Bacteria in Antibiotic Resistance: Ajax’ Shield or Achilles’ Heel?

    Page, Malcolm G. P.

    Pages 67-86

Buy this book

eBook $389.00
price for USA (gross)
  • ISBN 978-3-642-28951-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $489.00
price for USA
  • ISBN 978-3-642-28950-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $489.00
price for USA
  • ISBN 978-3-642-43249-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Antibiotic Resistance
Editors
  • Anthony R.M. Coates
Series Title
Handbook of Experimental Pharmacology
Series Volume
211
Copyright
2012
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-28951-4
DOI
10.1007/978-3-642-28951-4
Hardcover ISBN
978-3-642-28950-7
Softcover ISBN
978-3-642-43249-1
Series ISSN
0171-2004
Edition Number
1
Number of Pages
VIII, 192
Topics