Purinergic Signalling and the Nervous System

Authors: Burnstock, Geoffrey, Verkhratsky, Alexei

  • The first comprehensive overview of the purinergic signaling system 
  • This edition (vol. 1) focuses on purinergic transmission in both the peripheral and central nervous systems 
  • Companion volume (vol. 2) will focus on purinergic signaling in all non-neuronal tissues 
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eBook $219.00
price for USA (gross)
  • ISBN 978-3-642-28863-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-3-642-28862-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents.

In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

Table of contents (11 chapters)

  • Introduction

    Burnstock, Geoffrey (et al.)

    Pages 1-6

  • Early History of Purinergic Signalling

    Burnstock, Geoffrey (et al.)

    Pages 7-66

  • Purinergic Cotransmission

    Burnstock, Geoffrey (et al.)

    Pages 67-77

  • Mechanisms of ATP Release and Inactivation

    Burnstock, Geoffrey (et al.)

    Pages 79-118

  • Receptors for Purines and Pyrimidines

    Burnstock, Geoffrey (et al.)

    Pages 119-244

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-3-642-28863-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-3-642-28862-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Purinergic Signalling and the Nervous System
Authors
Copyright
2012
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-28863-0
DOI
10.1007/978-3-642-28863-0
Hardcover ISBN
978-3-642-28862-3
Edition Number
1
Number of Pages
XVIII, 715
Topics