Nucleic Acids and Molecular Biology

RNA Metabolism in Trypanosomes

Editors: Bindereif, Albrecht (Ed.)

  • Presents the latest findings on RNA metabolism
  • In depth analysis of trypanosome transcription mechanism
  • Written by experts in the field 
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  • ISBN 978-3-642-28687-2
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About this book

Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.

Table of contents (11 chapters)

  • RNA Polymerases and Transcription Factors of Trypanosomes

    Günzl, Arthur

    Pages 1-27

  • SL RNA Biogenesis in Kinetoplastids: A Long and Winding Road

    Sturm, Nancy R. (et al.)

    Pages 29-47

  • Pre-mRNA Splicing in Trypanosoma brucei: Factors, Mechanisms, and Regulation

    Preußer, Christian (et al.)

    Pages 49-77

  • mRNA Turnover in Trypanosomes

    Clayton, Christine

    Pages 79-97

  • tRNA Biogenesis and Processing

    Spears, Jessica L. (et al.)

    Pages 99-121

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-642-28687-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-642-28686-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-642-43325-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
RNA Metabolism in Trypanosomes
Editors
  • Albrecht Bindereif
Series Title
Nucleic Acids and Molecular Biology
Series Volume
28
Copyright
2012
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-28687-2
DOI
10.1007/978-3-642-28687-2
Hardcover ISBN
978-3-642-28686-5
Softcover ISBN
978-3-642-43325-2
Series ISSN
0933-1891
Edition Number
1
Number of Pages
VI, 274
Topics