Epigenetics and Human Health

Environmental Epigenomics in Health and Disease

Epigenetics and Disease Origins

Editors: Jirtle, Randy L, Tyson, Frederick L. (Eds.)

  • Provides evidence that environmental exposures during early development can alter the risk of developing medical conditions
  • Presents epigenetic processes that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain, discussing autism, schizophrenia and even sexual dimorphism in the developing brains of males and females.
  • Summarizes the latest epigenetic advances in the understanding of cancer development and progression, with a special focus on DNA methylation¬† alterations and their value in clinical oncology for cancer management
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eBook $169.00
price for USA (gross)
  • ISBN 978-3-642-23380-7
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  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-3-642-23379-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-3-642-42728-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Table of contents (12 chapters)

  • Epigenetics: How Genes and Environment Interact

    Jirtle, Randy L.

    Pages 3-30

  • Developmental Epigenomics and Metabolic Disease

    Gluckman, Peter D. (et al.)

    Pages 31-50

  • Sculpting Our Future: Environmental Nudging of the Imprintome

    Murphy, Susan K. (et al.)

    Pages 51-73

  • Complex Phenotypes: Epigenetic Manifestation of Environmental Exposures

    Faulk, Christopher (et al.)

    Pages 77-97

  • Epigenetic Effects of Ionizing Radiation

    Kovalchuk, Olga

    Pages 99-126

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-3-642-23380-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-3-642-23379-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-3-642-42728-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Environmental Epigenomics in Health and Disease
Book Subtitle
Epigenetics and Disease Origins
Editors
  • Randy L Jirtle
  • Frederick L. Tyson
Series Title
Epigenetics and Human Health
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-23380-7
DOI
10.1007/978-3-642-23380-7
Hardcover ISBN
978-3-642-23379-1
Softcover ISBN
978-3-642-42728-2
Series ISSN
2191-2262
Edition Number
1
Number of Pages
XV, 302
Topics