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Muscarinic Receptors

  • Book
  • © 2012

Overview

Editors:
  1. Allison D. Fryer

    1. UHN67, Department of Pulmonary and Critical Ca, Oregon Health & Science University, Portland, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Arthur Christopoulos

    1. , Department of Pharmacology, Monash Institute of Pharmaceutical Scien, Parkville, Australia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Neil M. Nathanson

    1. , Department of Pharmacology, University of Washington, Seattle, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides both a broad overview of muscarinic acetylcholine receptors and a detailed description of their molecular and cell biology and physiology, and current and potential future therapeutic applications of drugs targeted at the muscarinic system
  • Will be of interest to a wide range of researchers working in the areas of pharmacology, physiology, neuroscience, endocrinology, and receptor biology, and to basic and clinical scientists working in both universities and the pharmaceutical/biotech industry
  • Written by leading authorities in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 208)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Muscarinic Receptor Pharmacology and Signaling

    1. Front Matter

      Pages 1-1
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  3. Muscarinic receptor pharmacology and signaling

    1. Overview of Muscarinic Receptor Subtypes

      • Richard M. Eglen
      Pages 3-28

    2. Structure–Function Studies of Muscarinic Acetylcholine Receptors

      • Katie Leach, John Simms, Patrick M. Sexton, Arthur Christopoulos
      Pages 29-48

    3. Polymorphisms in Human Muscarinic Receptor Subtype Genes

      • Martin C. Michel, Christine A. Teitsma
      Pages 49-59

    4. Muscarinic Receptor Trafficking

      • Cindy Reiner, Neil M. Nathanson
      Pages 61-78

    5. Physiological Role of G-Protein Coupled Receptor Phosphorylation

      • Adrian J. Butcher, Kok Choi Kong, Rudi Prihandoko, Andrew B. Tobin
      Pages 79-94

    6. Novel Muscarinic Receptor Mutant Mouse Models

      • Jürgen Wess
      Pages 95-117

  4. Muscarinic Receptors in the CNS

    1. Front Matter

      Pages 119-119
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    2. Muscarinic Receptor Pharmacology and Circuitry for the Modulation of Cognition

      • Michael Bubser, Nellie Byun, Michael R. Wood, Carrie K. Jones
      Pages 121-166

    3. Muscarinic Agonists and Antagonists in Schizophrenia

      • Amanda R. Bolbecker, Anantha Shekhar
      Pages 167-190

    4. Muscarinic Pain Pharmacology: Realizing the Promise of Novel Analgesics by Overcoming Old Challenges

      • Dennis F. Fiorino, Miguel Garcia-Guzman
      Pages 191-221

    5. Muscarinic Modulation of Striatal Function and Circuitry

      • Joshua A. Goldberg, Jun B. Ding, D. James Surmeier
      Pages 223-241

    6. Muscarinic Receptors in Brain Stem and Mesopontine Cholinergic Arousal Functions

      • John S. Yeomans
      Pages 243-259

  5. Muscarinic Receptors in Autonomic Effector Organs

    1. Front Matter

      Pages 261-261
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    2. Muscarinic Receptor Agonists and Antagonists: Effects on Ocular Function

      • Frederick Mitchelson
      Pages 263-298

    3. Muscarinic Receptor Agonists and Antagonists: Effects on Cardiovascular Function

      • Robert D. Harvey
      Pages 299-316

    4. Muscarinic Receptor Antagonists: Effects on Pulmonary Function

      • Kalmia S. Buels, Allison D. Fryer
      Pages 317-341

    5. Muscarinic Agonists and Antagonists: Effects on Gastrointestinal Function

      • Frederick J. Ehlert, Kirk J. Pak, Michael T. Griffin
      Pages 343-374

    6. Muscarinic Agonists and Antagonists: Effects on the Urinary Bladder

      • Donna J. Sellers, Russ Chess-Williams
      Pages 375-400
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Keywords

About this book

Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.

Editors and Affiliations

  • UHN67, Department of Pulmonary and Critical Ca, Oregon Health & Science University, Portland, USA

    Allison D. Fryer

  • , Department of Pharmacology, Monash Institute of Pharmaceutical Scien, Parkville, Australia

    Arthur Christopoulos

  • , Department of Pharmacology, University of Washington, Seattle, USA

    Neil M. Nathanson

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