Nucleic Acids and Molecular Biology

Ribonucleases

Editors: Nicholson, Allen W. (Ed.)

  • Gives comprehensive, up-to-date overview on the major groups of ribonucleases
  • Puts latest knowledge about ribonucleases into a wider context, such as medical applications
  • Written by international experts
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About this book

Ribonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5’ or 3’ ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.

Table of contents (15 chapters)

  • The Superfamily of Vertebrate-Secreted Ribonucleases

    D’Alessio, Giuseppe

    Pages 1-34

  • Vertebrate Secretory (RNase A) Ribonucleases and Host Defense

    Rosenberg, Helene F.

    Pages 35-53

  • Antitumor Ribonucleases

    Ribó, Marc (et al.)

    Pages 55-88

  • RNase T2 Family: Enzymatic Properties, Functional Diversity, and Evolution of Ancient Ribonucleases

    MacIntosh, Gustavo C.

    Pages 89-114

  • Stress-Induced Ribonucleases

    Ivanov, Pavel (et al.)

    Pages 115-134

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-3-642-21078-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-3-642-21077-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-3-642-27090-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Ribonucleases
Editors
  • Allen W. Nicholson
Series Title
Nucleic Acids and Molecular Biology
Series Volume
26
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-21078-5
DOI
10.1007/978-3-642-21078-5
Hardcover ISBN
978-3-642-21077-8
Softcover ISBN
978-3-642-27090-1
Series ISSN
0933-1891
Edition Number
1
Number of Pages
XIV, 406
Topics