Overview
First advanced text for life scientists on numerical methods
Easy step-by-step introduction to numerical solutions
Installation guide for the free software GNU Octave
More than 30 programs (written in Octave) will provide templates for biochemical applications – available as supplementary electronic material
Analysis of experimental data by multi-parameter fits
Correlation of parameters, significance of the results
Includes supplementary material: sn.pub/extras
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Table of contents (9 chapters)
Keywords
About this book
Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.
Authors and Affiliations
Bibliographic Information
Book Title: Numerical Methods for the Life Scientist
Book Subtitle: Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB
Authors: Heino Prinz
DOI: https://doi.org/10.1007/978-3-642-20820-1
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2011
Hardcover ISBN: 978-3-642-20819-5Published: 06 August 2011
Softcover ISBN: 978-3-662-50587-8Published: 23 August 2016
eBook ISBN: 978-3-642-20820-1Published: 06 August 2011
Edition Number: 1
Number of Pages: IX, 149
Topics: Bioinformatics, Computational Biology/Bioinformatics, Mathematical and Computational Biology