Handbook of Experimental Pharmacology

Phosphodiesterases as Drug Targets

Editors: Francis, Sharron H., Conti, Marco, Houslay, Miles D. (Eds.)

  • Summarizes the major concepts related to the design and use of PDE inhibitors
  • Describes exciting fresh ideas and developments that are currently emerging in this dynamic and important field
  • Written by leading authorities in the field
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  • ISBN 978-3-642-17969-3
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Softcover $529.00
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About this book

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

Table of contents (20 chapters)

  • Phosphodiesterase Inhibitors: History of Pharmacology

    Schudt, Christian (et al.)

    Pages 1-46

  • Phosphodiesterase Inhibitors: Factors That Influence Potency, Selectivity, and Action

    Francis, Sharron H. (et al.)

    Pages 47-84

  • Pharmacology, Clinical Efficacy, and Tolerability of Phosphodiesterase-4 Inhibitors: Impact of Human Pharmacokinetics

    Tenor, Hermann (et al.)

    Pages 85-119

  • Structural Insight into the Substrate Specificity of Phosphodiesterases

    Ke, Hengming (et al.)

    Pages 121-134

  • A Fission Yeast-Based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity

    Demirbas, Didem (et al.)

    Pages 135-149

Buy this book

eBook $419.00
price for USA (gross)
  • ISBN 978-3-642-17969-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $529.00
price for USA
  • ISBN 978-3-642-17968-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $529.00
price for USA
  • ISBN 978-3-642-26945-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Phosphodiesterases as Drug Targets
Editors
  • Sharron H. Francis
  • Marco Conti
  • Miles D. Houslay
Series Title
Handbook of Experimental Pharmacology
Series Volume
204
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-17969-3
DOI
10.1007/978-3-642-17969-3
Hardcover ISBN
978-3-642-17968-6
Softcover ISBN
978-3-642-26945-5
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XVIII, 522
Topics