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Heart Rate and Rhythm

Molecular Basis, Pharmacological Modulation and Clinical Implications

  • Book
  • © 2011

Overview

Editors:
  1. Onkar N. Tripathi

    1. Life Sciences Academy, Lucknow, India

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  2. Ursula Ravens

    1. Medizinische Fakultät, Inst. für Pharmakologie u. Toxikologie, TU Dresden, Dresden, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Michael C. Sanguinetti

    1. Cardiovascular Research &, Training Inst. (CVRTI), University of Utah, Salt Lake City, USA

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  • Introduces into the molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms
  • Written by experts from various fields
  • Of interest for researchers in cardiac electrophysiology, cell biology, and pharmacology
  • Includes supplementary material: sn.pub/extras

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Table of contents (37 chapters)

  1. Front Matter

    Pages i-xxii
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  2. Normal Cardiac Rhythm and Pacemaker Activity

    1. Front Matter

      Pages 1-1
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    2. Cardiac Ion Channels and Heart Rate and Rhythm

      • Onkar Nath Tripathi
      Pages 3-31

    3. Ionic Basis of the Pacemaker Activity of SA Node Revealed by the Lead Potential Analysis

      • Yukiko Himeno, Chae Young Cha, Akinori Noma
      Pages 33-58

    4. The “Funny” Pacemaker Current

      • Andrea Barbuti, Annalisa Bucchi, Raffaella Milanesi, Georgia Bottelli, Alessia Crespi, Dario DiFrancesco
      Pages 59-81

    5. Novel Perspectives on Cardiac Pacemaker Regulation: Role of the Coupled Function of Sarcolemmal and Intracellular Proteins

      • Victor A. Maltsev, Tatiana M. Vinogradova, Edward G. Lakatta
      Pages 83-99

    6. Pacemaker Activity of the SA Node: Insights from Dynamic-Clamp Experiments

      • Ronald Wilders, Antoni C. G. van Ginneken, Arie O. Verkerk
      Pages 101-117

    7. Heart Rate Variability: Molecular Mechanisms and Clinical Implications

      • Kishore K. Deepak
      Pages 119-132

    8. Mechano-Electric Feedback in the Heart: Effects on Heart Rate and Rhythm

      • T. Alexander Quinn, Rebecca A. Bayliss, Peter Kohl
      Pages 133-151

  3. Modeling

    1. Front Matter

      Pages 153-153
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    2. A Historical Perspective on the Development of Models of Rhythm in the Heart

      • Penelope J. Noble, Denis Noble
      Pages 155-173

    3. Simulation of Cardiac Action Potentials

      • Jonathan D. Moreno, Colleen E. Clancy
      Pages 175-194

  4. Cardiac Development and Anatomy

    1. Front Matter

      Pages 195-195
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    2. Development of Pacemaker Activity in Embryonic and Embryonic Stem Cell-Derived Cardiomyocytes

      • Huamin Liang, Michael Reppel, Ming Tang, Jürgen Hescheler
      Pages 197-209

    3. Molecular Basis of the Electrical Activity of the Atrioventricular Junction and Purkinje Fibres

      • Halina Dobrzynski, Oliver Monfredi, Ian D. Greener, Andrew Atkinson, Shin Inada, Mary-Anne Taube et al.
      Pages 211-230

    4. Molecular Basis and Genetic Aspects of the Development of the Cardiac Chambers and Conduction System: Relevance to Heart Rhythm

      • Martijn L. Bakker, Vincent M. Christoffels, Antoon F. M. Moorman
      Pages 231-253

    5. Role of the T-Tubules in the Response of Cardiac Ventricular Myocytes to Inotropic Interventions

      • C. H. Orchard, F. Brette, A. Chase, M. R. Fowler
      Pages 255-266

  5. Mechanisms of Acquired Arrhythmia

    1. Front Matter

      Pages 267-267
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    2. An Overview of Spiral- and Scroll-Wave Dynamics in Mathematical Models for Cardiac Tissue

      • Rupamanjari Majumder, Alok Ranjan Nayak, Rahul Pandit
      Pages 269-282

    3. Post-infarction Remodeling and Arrhythmogenesis: Molecular, Ionic, and Electrophysiological Substrates

      • Nabil El-Sherif
      Pages 283-304
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Keywords

About this book

Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms.

Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

Reviews

From the reviews:

“Heart Rate reigns as one of 2011’s best. Here, physicians are presented with an acute review of how changes in heart rate can be used as a marker to assess patients in the clinical setting. … the writers also extend their treatise to practicing clinicians and ways that the information can be used to better treat patients. Noted for its clear delineation of complex data; with skilled use of illustrations and graphs that re-enforce key points chapter-by-chapter.” (John Aiello, The Electric Review, July, 2011)

Editors and Affiliations

  • Life Sciences Academy, Lucknow, India

    Onkar N. Tripathi

  • Medizinische Fakultät, Inst. für Pharmakologie u. Toxikologie, TU Dresden, Dresden, Germany

    Ursula Ravens

  • Cardiovascular Research &, Training Inst. (CVRTI), University of Utah, Salt Lake City, USA

    Michael C. Sanguinetti

Bibliographic Information

  • Book Title: Heart Rate and Rhythm

  • Book Subtitle: Molecular Basis, Pharmacological Modulation and Clinical Implications

  • Editors: Onkar N. Tripathi, Ursula Ravens, Michael C. Sanguinetti

  • DOI: https://doi.org/10.1007/978-3-642-17575-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2011

  • Hardcover ISBN: 978-3-642-17574-9Published: 06 May 2011

  • eBook ISBN: 978-3-642-17575-6Published: 02 May 2011

  • Edition Number: 1

  • Number of Pages: XXII, 678

  • Topics: Molecular Medicine, Human Physiology, Pharmacology/Toxicology, Cardiology

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