Research and Perspectives in Alzheimer's Disease

Two Faces of Evil: Cancer and Neurodegeneration

Editors: Curran, Thomas, Christen, Yves (Eds.)

  • Brings together experts from the fields of cancer research and neurodegeneration
  • Seeks to stimulate transdisciplinary interactions with the hope of accelerating progress
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  • ISBN 978-3-642-16602-0
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  • ISBN 978-3-642-16601-3
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  • ISBN 978-3-642-26771-0
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About this book

The two greatest medical fears of the aging population are cancer and Alzheimer’s disease. Despite dramatic advances in understanding the molecular etiology of these disorders, therapeutic options for many patients with advanced disease have changed little and outcomes remain dismal. Paradoxically, recent findings suggest that some of the same molecules and biochemical processes underlying cancer may also participate in neurodegeneration. Therefore, it would be very useful to bring together experts from the fields of cancer research and neurodegeneration for discussions of the latest advances and ideas, with a particular emphasis on areas of overlap, to stimulate transdisciplinary interactions with the hope of accelerating progress. Cancer arises as a consequence of a breakdown in the genetic and epigenetic processes governing cell proliferation and cell death. Alterations in several classes of signaling molecules, both oncogenes and tumor suppressor genes, lead to uncontrolled cell growth. Over the past two decades, details of the intricate signaling pathways, from cell surface receptors through protein kinase cascades, transcription factors and modulators of chromatin, as well as the DNA damage response pathways linked to cell cycle control that guard the genome, have been uncovered. In some instances, key regulatory proteins have provided novel targets for development of small molecule inhibitors that are currently being tested in the clinic. The development of the nervous system relies on many of the signaling pathways and growth control processes that go awry in cancer. However, in mature neurons, the very same signaling proteins participate in transduction cascades linking short-term stimuli, elicited by synaptic stimulation, to long-term alterations in neuronal circuits through the regulation of gene expression and chromatin structure. These long-term adaptive modifications lead to changes in synaptic structure and function that contribute to learning and memory. The persistence of growth regulatory molecules in postmitotic neurons provides an opportunity for their contribution to pathophysiological processes resulting in neuronal loss. Recently, evidence has accumulated suggesting an association of cell cycle proteins and signal transduction proteins with neurodegeneration. Indeed, inhibitors of histone deacetylation have shown promise both as anti-cancer agents and in the prevention of neuronal loss

Reviews

From the reviews:

“The authors look at the etiology and molecular pathophysiology of several genes involved in cellular demise and cell proliferation. … The book is going to be of interest to cell biologists primarily and anyone with an interest in cancer or neurodegeneration.” (Joseph J. Grenier, Amazon.com, September, 2013)

Table of contents (13 chapters)

  • Updating the Mammalian Cell Cycle: The Role of Interphase Cdks in Tissue Homeostasis and Cancer

    Barbacid, Mariano

    Pages 1-16

  • The Role of Cdk5 as a Cell Cycle Suppressor in Post-mitotic Neurons

    Herrup, Karl

    Pages 17-25

  • Actin-SRF Signaling in the Developing and Mature Murine Brain

    Nordheim, Alfred (et al.)

    Pages 27-39

  • The E3 Ubiquitin Ligase Ube3A Regulates Synaptic Function Through the Ubiquitination of Arc

    Griffith, Eric C. (et al.)

    Pages 41-56

  • Targeting Children’s Brain Tumors: Development of Hedgehog Pathway Inhibitors for Medulloblastoma

    Curran, Tom

    Pages 57-71

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-642-16602-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-642-16601-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-642-26771-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Two Faces of Evil: Cancer and Neurodegeneration
Editors
  • Thomas Curran
  • Yves Christen
Series Title
Research and Perspectives in Alzheimer's Disease
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-16602-0
DOI
10.1007/978-3-642-16602-0
Hardcover ISBN
978-3-642-16601-3
Softcover ISBN
978-3-642-26771-0
Series ISSN
0945-6066
Edition Number
1
Number of Pages
XIV, 166
Topics