Progress in Molecular and Subcellular Biology

Long Non-Coding RNAs

Editors: Ugarković, Ðurðica (Ed.)

  • Gives overview of the rapidly advancing field of long non-coding RNAs
  • Describes the biological functions of long non-coding RNAs in all model systems (from microorganism to mammals)
  • Covers epigenetic and non-epigenetic mechanisms of gene regulation through long non-coding RNAs
  • Written by experts in the field
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About this book

Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs.

This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.

Table of contents (6 chapters)

  • Transcriptional and Posttranscriptional Programming by Long Noncoding RNAs

    Radha Raman Pandey, Chandrasekhar Kanduri

    Pages 1-27

  • Long Noncoding RNA as a Regulator for Transcription

    Riki Kurokawa

    Pages 29-41

  • Long Noncoding RNAs and X Chromosome Inactivation

    Cristina Gontan, Iris Jonkers, Joost Gribnau

    Pages 43-64

  • TERRA: Long Noncoding RNA at Eukaryotic Telomeres

    Rajika Arora, Catherine M. C. Brun, Claus M. Azzalin

    Pages 65-94

  • Transcription of Satellite DNAs in Mammals

    Claire Vourc’h, Giuseppe Biamonti

    Pages 95-118

Buy this book

eBook $179.00
price for USA (gross)
  • ISBN 978-3-642-16502-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-3-642-16501-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.00
price for USA
  • ISBN 978-3-642-26655-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Long Non-Coding RNAs
Editors
  • Ðurðica Ugarković
Series Title
Progress in Molecular and Subcellular Biology
Series Volume
51
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-16502-3
DOI
10.1007/978-3-642-16502-3
Hardcover ISBN
978-3-642-16501-6
Softcover ISBN
978-3-642-26655-3
Series ISSN
0079-6484
Edition Number
1
Number of Pages
XII, 208
Topics