Advances in Anatomy, Embryology and Cell Biology

Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells

Authors: Spanel-Borowski, Katharina

  • Explores novel concepts in the role of innate immunity in disorders of the cyclic ovary
  • Decribes processes and current research in detail
  • Examines the prospects for new therapies for such ovarian disorders as anovulations, luteal phase
  • insufficiency, and autoimmune failures
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About this book

The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK+) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK+ cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.

Table of contents (8 chapters)

  • Background

    Spanel-Borowski, Katharina

    Pages 1-6

  • Materials and Methods

    Spanel-Borowski, Katharina

    Pages 7-15

  • Footmarks of INIM

    Spanel-Borowski, Katharina

    Pages 17-34

  • Cytokeratin-Positive Cells (CK+) as Potential Dendritic Cells

    Spanel-Borowski, Katharina

    Pages 35-44

  • Characterization of Isolated CK+ Cells

    Spanel-Borowski, Katharina

    Pages 45-76

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-642-16077-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $189.00
price for USA
  • ISBN 978-3-642-16076-9
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells
Authors
Series Title
Advances in Anatomy, Embryology and Cell Biology
Series Volume
209
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-16077-6
DOI
10.1007/978-3-642-16077-6
Softcover ISBN
978-3-642-16076-9
Series ISSN
0301-5556
Edition Number
1
Number of Pages
XV, 110
Number of Illustrations and Tables
11 b/w illustrations, 22 illustrations in colour
Topics