Statistics in Clinical Vaccine Trials

Authors: Nauta, Jozef

  • First comprehensive text on the current state of the statistical methodology for clinical vaccines trials
  • Many worked-out real-life examples
  • SAS codes for the more complex examples provided
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eBook $89.00
price for USA (gross)
  • ISBN 978-3-642-14691-6
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  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.00
price for USA
  • ISBN 978-3-642-14690-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $119.00
price for USA
  • ISBN 978-3-642-44191-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
About this book

This monograph offers well-founded training and expertise on the statistical analysis of data from clinical vaccine trials, i.e., immunogenicity and vaccine field efficacy studies. The book's scope is practical rather than theoretical. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the statistical methodology. Many real-life examples and SAS codes are presented, making application of the methods straightforward. Topics discussed include maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of equivalence and non-inferiority immunogenicity trial data, analysis of data from vaccine field efficacy trials (including data from studies with recurrent infection data), fitting protection curves to data of challenge or field efficacy studies, and the analysis of vaccine safety data.

Reviews

From the book reviews:

“The presentation of the book is lucid. The author is to be congratulated for mixing his vast practical experience with his knowledge to make this book readable and practically valuable.” (Subir Ghosh, Technometrics, Vol. 55 (3), August, 2013)


Table of contents (9 chapters)

  • Basic Concepts of Vaccine Immunology

    Nauta, Jozef

    Pages 1-12

  • Humoral and Cellular Immunity

    Nauta, Jozef

    Pages 13-17

  • Standard Statistical Methods for the Analysis of Immunogenicity Data

    Nauta, Jozef

    Pages 19-46

  • Antibody Titres and Two Types of Bias

    Nauta, Jozef

    Pages 47-55

  • Adjusting for Imbalance in Pre-Vaccination State

    Nauta, Jozef

    Pages 57-65

Buy this book

eBook $89.00
price for USA (gross)
  • ISBN 978-3-642-14691-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.00
price for USA
  • ISBN 978-3-642-14690-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $119.00
price for USA
  • ISBN 978-3-642-44191-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Statistics in Clinical Vaccine Trials
Authors
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-14691-6
DOI
10.1007/978-3-642-14691-6
Hardcover ISBN
978-3-642-14690-9
Softcover ISBN
978-3-642-44191-2
Edition Number
1
Number of Pages
XVIII, 153
Topics