Advances in Anatomy, Embryology and Cell Biology

Functional Anatomy of the Sleep-Wakefulness Cycle: Wakefulness

Authors: Reinoso-Suárez, Fernando, de Andrés, Isabel, Garzón, Miguel

  • The authors present a detailed review and update of the structures involved in the phase of wakefulness (W), including their morphological, functional and chemical characteristics, as well as their anatomical connections

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About this book

Wakefulness is a necessary, active and periodic brain state, with a circadian and homeostatic regulation and precisely meshed with other states into the sleep-wakefulness cycle. This monograph first overviews the historical background and current understanding of the neuronal systems generating and/or maintaining the various phases of the sleep-wakefulness cycle. A key cellular correlate of wakefulness is a sustained mode of high activity and plasticity in the closely intertwined circuits of the cortex and thalamus, the “thalamo-cerebral cortex unity”. The second part of the monograph provides an in-depth review of recent advances on the anatomy, physiology and neurochemistry of the neuronal groups known to drive the “thalamo-cerebral cortex unity” into their wakefulness mode, and to keep them in such mode. Interestingly, these neuronal groups are located in the brainstem, hypothalamus or basal forebrain; collectively, they are known as the “ascending reticular activating system”. Neurotransmitter-specific pathways arising from these neuronal groups target the thalamus and cortex. The various neurotransmitters interact on postsynaptic cortical or thalamic cells to fine-tune their excitability and plasticity, exerting powerful influences on the perceptual and cognitive processes as well as attentional, emotional, motivational, behavioral and arousal states. In turn, corticofugal axons reach the neuronal groups of the “ascending reticular activating system”, and thus the awake “thalamo-cerebral cortex unity” is in position to modulate their activity

Table of contents (3 chapters)

  • The Sleep–Wakefulness Cycle

    Reinoso-Suárez, Fernando (et al.)

    Pages 1-4

  • Revision of the Publications Describing the Anatomical Connections and Effects of Lesions and Electrical Stimulation of Brain Structures on the Sleep–Wakefulness Cycle

    Reinoso-Suárez, Fernando (et al.)

    Pages 5-61

  • Functional Anatomy of Wakefulness

    Reinoso-Suárez, Fernando (et al.)

    Pages 63-109

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-642-14626-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $189.00
price for USA
  • ISBN 978-3-642-14625-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Functional Anatomy of the Sleep-Wakefulness Cycle: Wakefulness
Authors
Series Title
Advances in Anatomy, Embryology and Cell Biology
Series Volume
208
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-14626-8
DOI
10.1007/978-3-642-14626-8
Softcover ISBN
978-3-642-14625-1
Series ISSN
0301-5556
Edition Number
1
Number of Pages
XII, 130
Number of Illustrations and Tables
42 b/w illustrations, 11 illustrations in colour
Topics