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Molecular Basis of Multiple Sclerosis

The Immune System

  • Book
  • © 2010

Overview

Editors:
  1. Roland Martin

    1. Institut für Neuroimmunologie und, Klinische Multiple-Sklerose-Forschung, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

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  2. Andreas Lutterotti

    1. , Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

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    You can also search for this editor in PubMed   Google Scholar

  • Investigates the molecular basis of multiple sclerosis
  • Summarizes the most recent advances in this highly complex field
  • Written by experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 51)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Genetics of Multiple Sclerosis

    • Jan Hillert
    Pages 1-19

  3. Potential Triggers of MS

    • Jane E. Libbey, Robert S. Fujinami
    Pages 21-42

  4. Immunological Basis for the Development of Tissue Inflammation and Organ-Specific Autoimmunity in Animal Models of Multiple Sclerosis

    • Thomas Korn, Meike Mitsdoerffer, Vijay K. Kuchroo
    Pages 43-74

  5. T-Cells in Multiple Sclerosis

    • Christopher Severson, David A. Hafler
    Pages 75-98

  6. B Cells and Antibodies in MS

    • Markus Reindl, Bettina Kuenz, Thomas Berger
    Pages 99-113

  7. Cooperation of B Cells and T Cells in the Pathogenesis of Multiple Sclerosis

    • Martin S. Weber, Bernhard Hemmer
    Pages 115-126

  8. Role of NK Cells and Invariant NKT Cells in Multiple Sclerosis

    • Kaori Sakuishi, Sachiko Miyake, Takashi Yamamura
    Pages 127-147

  9. Antigen Processing and Presentation in Multiple Sclerosis

    • Christina Stoeckle, Eva Tolosa
    Pages 149-172

  10. Immune-Mediated CNS Damage

    • Katrin Kierdorf, Yiner Wang, Harald Neumann
    Pages 173-196

  11. Neuro-Immune Crosstalk in CNS Diseases

    • Martin Kerschensteiner, Edgar Meinl, Reinhard Hohlfeld
    Pages 197-216

  12. Prospects for Antigen-Specific Tolerance Based Therapies for the Treatment of Multiple Sclerosis

    • Danielle M. Turley, Stephen D. Miller
    Pages 217-235

  13. Immuno-Therapeutic Potential of Haematopoietic and Mesenchymal Stem Cell Transplantation in MS

    • Paolo A. Muraro, Antonio Uccelli
    Pages 237-257

  14. Multiple Sclerosis Therapies: Molecular Mechanisms and Future

    • Paulo Fontoura, Hideki Garren
    Pages 259-285

  15. Examination of the Role of MRI in Multiple Sclerosis: A Problem Orientated Approach

    • Henry F. McFarland
    Pages 287-301

  16. Back Matter

    Pages 303-307
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Keywords

About this book

Despite major efforts by the scientific community over the years, our understanding of the pathogenesis or the mechanisms of injury of multiple sclerosis is still limited. Consequently, the current strategies for treatment and management of patients are limited in their efficacy. The mechanisms of tissue protection and repair are probably even less understood. One reason for these limitations is the enormous complexity of the disease and every facet of its pathogenesis, the mechanisms of tissue injury, the diagnostic procedures and finally the efficacy of treatments and their side effects. The aim of this book is to review the most recent advances made in this highly complex field.

Editors and Affiliations

  • Institut für Neuroimmunologie und, Klinische Multiple-Sklerose-Forschung, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

    Roland Martin

  • , Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

    Andreas Lutterotti

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