Childhood Leukemia

1. Front Matter

   Pages i-x

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2. Genetics and the Epidemiology of Leukemia in Children

   1. Front Matter

      Pages 1-1

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   2. Epidemiology of Acute Childhood Leukemia

      • Julie A. Ross, Kimberly J. Johnson, Logan G. Spector, John H. Kersey

      Pages 3-26

3. Biology of Pediatric Leukemia

   1. Front Matter

      Pages 27-27

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   2. The Biology of Acute Lymphoblastic Leukemia

      • William L. Carroll, Mignon Loh, Andrea Biondi, Cheryl Willman

      Pages 29-61

   3. Biology of Acute Myeloid Leukemia

      • Robert J. Arceci, Soheil Meshinchi

      Pages 63-76

4. Treatment Considerations in Childhood Leukemia

   1. Front Matter

      Pages 77-77

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   2. Classification and Treatment of Acute Lymphoblastic Leukemia

      • Stephen P. Hunger, Valentino Conter, Elizabeth A. Raetz, Maria Grazia Valsecchi, Guenter Henze

      Pages 79-120

   3. Treatment of Acute Myeloid Leukemia

      • Brenda Gibson, John Perentesis, Todd A. Alonzo, Gertjan J. L. Kaspers

      Pages 121-160

5. The Impact of Pharmacogenetics and Pharmacogenomics on Childhood Leukemia

   1. Front Matter

      Pages 161-161

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   2. Pharmacogenetic and Pharmacogenomic Considerations in the Biology and Treatment of Childhood Leukemia

      • Jun J. Yang, Parinda A. Mehta, Mary V. Relling, Stella M. Davies

      Pages 163-189

6. The Potential Role of Biologically Targeted Therapy for Childhood Leukemia

   1. Front Matter

      Pages 191-191

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   2. Promising Targeted Agents

      • Patrick Brown, Gregory H. Reaman, Nita L. Seibel, Pamela Kearns

      Pages 193-214

   3. Strategies for New Agent Development and Clinical Trial Considerations

      • Malcolm Smith, Meenakshi Devidas, Keith Wheatley, Richard B. Lock, Sally Hunsberger

      Pages 215-241

7. Late Effects of Leukemia and Its Therapy

   1. Front Matter

      Pages 243-243

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   2. Late Sequelae in Children with Acute Lymphoblastic Leukemia: Impact on Long-Term Survival and Quality of Life

      • Joseph P. Neglia, Maura O’Leary, Smita Bhatia

      Pages 245-263

   3. Acute Toxicities, Late Sequelae, and Quality of Survivorship in Children with Acute Myeloid Leukemia: The Impact of Allogeneic Stem Cell Transplant

      • Julianne Byrne, John Horan, H. Stacy Nicholson

      Pages 265-282

8. Psychosocial Implications of Acute Leukemia Diagnosis and Treatment for Children and Families

   1. Front Matter

      Pages 283-283

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   2. Appreciation and the Interdisciplinary Management of the Psychosocial Impact of Leukemia on Children and Their Families

      • Anne L. Angiolillo, Momcilo Jankovic, Riccardo Haupt, Kathleen Ruccione, E. Anne Lown, Robert B. Noll

      Pages 285-301

9. Global Strategies to Improve Leukemia Care and Outcome for Children

   1. Front Matter

      Pages 303-303

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This book is a comprehensive and up-to-date compendium on all aspects of childhood leukemia. After introductory chapters on the epidemiology and biology of pediatric leukemia, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. Promising targeted agents are discussed, and strategies for the development of new agents are appraised. The late effects of leukemia and its therapy are then considered in depth, with due attention to management of the psychosocial impact of the disease. Finally, global strategies to improve leukemia care and outcome are reviewed, and future directions discussed. The authors are internationally recognized experts and offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of pediatric leukemia and will prove invaluable to specialists, generalists, and trainees alike.

• Acute Leukemia
• Biology Treatment
• Children

From the reviews:

“This comprehensive book presents current information on childhood acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). … the book appears to be written for practitioners in pediatric oncology, particularly those who specialize in leukemias. … The combination of clinical and basic knowledge is the best thing about this book. … This book offers the most up-to-date information on childhood acute leukemias comprehensively and concisely. I would recommend it to fellows and junior faculty who want to learn about childhood leukemia in depth.” (Nobuko Hijiya, Doody’s Review Service, April, 2011)

• School of Medicine & Health Sciences, George Washington University, Bethesda, USA

  Gregory H. Reaman

• Cincinnati Children's Hospital, Medical Center (CCHMC), University of Cincinnati, Cincinnati, USA

  Franklin O. Smith

Gregory H. Reaman, M.D., is Chair of the Children’s Oncology Group (COG) since its inception in 2000 resulting from the merger of four legacy pediatric cancer research organizations, is comprised of over 200 member institutions, dedicated to clinical, translational, and epidemiology research in childhood cancer. Dr. Reaman is a Professor of Pediatrics at The George Washington University School of Medicine and Health Sciences and a member of the Division of Hematology-Oncology at the Children’s National Medical Center in Washington, D.C., which he directed for nearly 18 years, and Executive Director Emeritus of the Center for Cancer and Blood Disorders. Dr. Reaman serves or has served on the Editorial Boards of Leukemia, Journal of Clinical Oncology, Journal of Pediatric Hematology/Oncology, Pediatric Blood and Cancer, The Oncologist, Cancer, and Physicians Data Query (PDQ), National Cancer Institute as well as the ASCO Cancer Foundation’s www.cancer.net. He has served as an Associate Editor of Cancer and Leukemia and Lymphoma. Previously, he served on the Board of Directors of the American Cancer Society and chaired its Task Force on Children and Cancer. Dr. Reaman served on the Board of Directors of the American Society of Clinical Oncology and has served on the ASCO Patient Education Committee, the Education and Program Committees, the Grant Selection Committee, and was the Chair of the ASCO Membership Committee. Also, he was a member of the Food and Drug Administration’s Oncologic Drugs Advisory Committee and continues as a member of its Pediatric Subcommittee. He was a member of the NIH Roadmap Working Group. Additionally, he is a member of the Alliance for Childhood Cancer, a member of the Data Safety Monitoring Board of the National Cancer Institute’s Clinical Oncology Program, and a member of the NCI’s Translational Research Working Group. He is the author of more than 250 peer-reviewed manuscripts resulting from long-standing interests inacute leukemia biology and treatment and development of new drugs for pediatric cancer. Franklin O. Smith, III, M.D., is Vice-Chair of the Children’s Oncology Group (COG). The COG, since its inception in 2000 resulting from the merger of four legacy pediatric cancer research organizations, is comprised of over 200 member institutions, dedicated to clinical, translational, and epidemiology research in childhood cancer. Dr. Smith is the Marjory J. Johnson Professor of Pediatrics at the University of Cincinnati College of Medicine. He has been the Director of the Division of Hematology/Oncology at Cincinnati Children’s Hospital Medical Center (CCHMC) since 2001. He also serves as the Director of the Pediatric Hematology/Oncology Fellowship Training Program at CCHMC. Dr. Smith serves or has served on the Editorial Boards of Blood, the British Journal of Haematology, the Journal of Hematotherapy and Stem Cell Research, and Physicians Data Query (PDQ), National Cancer Institute. He has served as a Section Editor of Cancer Research Therapy and Control, Editor for Medscape General Medicine, Topics in Pediatric Leukemia, and currently serves as Editor of Case Reports in Medicine. Previously, he served on the Board of Directors and as Treasurer of the Foundation for the Accreditation of Cellular Therapies (FACT). Additionally, he is a member of the Sickle Cell Data Safety Monitoring Board of the National Heart, Lung and Blood Institute. He is the author of more than 100 peer-reviewed manuscripts.

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