Research and Perspectives in Endocrine Interactions

Novel Insights into Adipose Cell Functions

Editors: Clément, Karine, Spiegelman, Bruce M. (Eds.)

  • Obesity is considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders. This volume provides insights into the biology of a complex endocrine organ: the adipose tissue

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Hardcover $259.00
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About this book

Obesity is considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders. Environmental, behavioural, genetic, epigenetic and multiple biological factors interact to cause obesity. In this context adipose tissue depots have been under focus in the last decades and pivotal concepts have emerged from the studies of their complex biology. While the white adipose tissue (WAT) is the main energy repository in the body (mobilizing fatty acids according to body needs) thanks to white adipocyte properties, WAT is also a multicellular organ communicating with other body organs (brain, muscles, liver, pancreas, heart, vessels, etc…) via complex networks of endocrine signals. The discovery of leptin in 1994 led to recognize WAT as a master organ at the crossroad of a myriad of physiological interactions to control food intake, energy balance, glucose and lipid metabolism, immunity and reproduction. The phenotype, amount and biology of each WAT component are profoundly altered in human obesity. Adipose plasticity also accounts for the extraordinary capacity of adipose precursors to differentiate into functional cardiomyocytes, osteoblasts, haematopoietic and neural cells, a convenient property for regenerative medicine. Finally, while initially thought to exert a negligible role in humans, the discovery of brown adipose tissue in adults stimulates a novel interest for this tissue with high capacity to oxidize fatty acids

Table of contents (13 chapters)

  • Pathological Alteration of Human Adipose Tissue in Obesity

    Clément, Karine

    Pages 1-13

  • Dynamics of Human Adipose Tissue. Regulatory Mechanisms and Consequences for Fat Cells and the Whole Body

    Arner, Peter

    Pages 15-19

  • Metabolism of Fatty Acids in Adipocytes

    Dinel, A. L. (et al.)

    Pages 21-43

  • The Role of Hypoxia in Adipocyte Function and Dysfunction

    Trayhurn, Paul (et al.)

    Pages 45-60

  • Brown Adipose Tissue In Humans: A New Target for Anti-Obesity Therapy

    Enerbäck, Sven

    Pages 61-66

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-642-13517-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-642-13516-3
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
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Bibliographic Information

Bibliographic Information
Book Title
Novel Insights into Adipose Cell Functions
Editors
  • Karine Clément
  • Bruce M. Spiegelman
Series Title
Research and Perspectives in Endocrine Interactions
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag GmbH Berlin Heidelberg
eBook ISBN
978-3-642-13517-0
DOI
10.1007/978-3-642-13517-0
Hardcover ISBN
978-3-642-13516-3
Series ISSN
1861-2253
Edition Number
1
Number of Pages
XI, 147
Topics