Current Topics in Microbiology and Immunology

Cell Entry by Non-Enveloped Viruses

Editors: Johnson, John E. (Ed.)

  • Examines the means by which non-enveloped viruses penetrate cellular membranes during cell entry
  • Helps elucidate the mechanisms of non-enveloped virus membrane penetration in general
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About this book

Non enveloped viruses constitute an important class of medically significant pathogens. They encode their proteins in single (ss) and double strand (ds) RNA and DNA genomes and display a variety of sizes and structures. In this volume experts in the field provide up to date descriptions of many characteristics associated with the ssRNA noda, picorna and calciviruses, the dsRNA reo and rotaviruses, the ssDNA parvoviruses and the dsDNA polyoma and adenoviruses. While many aspects of these viruses have been addressed previously, this volume specifically focuses on the issue of their entry into cells, with particular attention to the translocation of the viral genome through a membrane, without the aid of inter-membrane fusion that is common and reasonably well understood in enveloped viruses. Sufficient detail has been revealed in most of the viruses discussed in this volume to establish a credible argument for convergent evolution. A variety of mechanisms are described to generate and tightly control the exposure of a fusion-like peptide or an entire gene product that facilitates membrane permeation and genome delivery into the cytoplasm and, for the DNA viruses, the nucleus. Since there is no viral membrane to fuse with the cellular membrane, the events at this interface are different from those associated with enveloped viruses and with the various fusion events associated with normal cellular function. Thus, while the factors critical for this process to occur have been well established for many of these viruses, a specific mechanism for genome penetration is yet to be determined. We believe that this volume will provide a reference of enduring value for the non enveloped virus field and our hope is that the focus on entry and genome translocation across a cellular membrane will stimulate new ideas and mechanistic studies of this critically important process.

Reviews

From the reviews:

“This book contains detailed, up-to-date descriptions of cellular entry mechanisms of non-enveloped viruses, such as ssRNA viruses (nodavirus, picornavirus, calicivirus), dsRNA viruses (orthoreovirus, rotavirus), ssDNA viruses (parvovirus) and dsDNA viruses (polyomavirus, adenovirus). … The book is strongly recommended to established virologists, molecular and structural biologists, and young scientists working in these areas.” (Ulrich Desselberger, Microbiology Today, May, 2011)

Table of contents (8 chapters)

  • Flock House Virus: A Model System for Understanding Non-Enveloped Virus Entry and Membrane Penetration

    Odegard, Amy (et al.)

    Pages 1-22

  • The Caliciviruses

    Katpally, Umesh (et al.)

    Pages 23-41

  • Picornaviruses

    Tuthill, Tobias J. (et al.)

    Pages 43-89

  • From Touchdown to Transcription: The Reovirus Cell Entry Pathway

    Danthi, Pranav (et al.)

    Pages 91-119

  • Rotavirus Cell Entry

    Baker, Matthew (et al.)

    Pages 121-148

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-642-13332-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-642-13331-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-642-26469-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cell Entry by Non-Enveloped Viruses
Editors
  • John E. Johnson
Series Title
Current Topics in Microbiology and Immunology
Series Volume
343
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-13332-9
DOI
10.1007/978-3-642-13332-9
Hardcover ISBN
978-3-642-13331-2
Softcover ISBN
978-3-642-26469-6
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIV, 230
Topics