Hodgkin Lymphoma

1. Front Matter

   Pages i-ix

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2. From Hodgkin’s Disease to Hodgkin Lymphoma

   1. Front Matter

      Pages 1-1

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   2. Epidemiology

      • Sally L. Glaser, Ellen T. Chang, Christina A. Clarke, Theresa H. Keegan

      Pages 3-20

   3. The Role of Viruses in the Genesis of Hodgkin Lymphoma

      • Ruth F. Jarrett

      Pages 21-32

   4. Pathology and Molecular Pathology of Hodgkin Lymphoma

      • Andreas Rosenwald, Ralf Küppers

      Pages 33-48

   5. Microenvironment, Cross-Talk, and Immune Escape Mechanisms

      • Lydia Visser, Anke van den Berg, Sibrand Poppema, Arjan Diepstra

      Pages 49-61

3. Diagnosis and Treatment

   1. Front Matter

      Pages 63-63

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   2. Clinical Evaluation

      • Jim Armitage, Christian Gisselbrecht

      Pages 65-76

   3. Functional Imaging

      • Martin Hutchings, Andrea Gallamini

      Pages 77-95

   4. Prognostic Factors

      • Lena Specht, Dirk Hasenclever

      Pages 97-115

   5. Principles of Radiation Techniques in Hodgkin Lymphoma

      • Joachim Yahalom, Richard T. Hoppe

      Pages 117-139

   6. Principles of Chemotherapy in Hodgkin Lymphoma

      • Patrice Carde, Peter Johnson

      Pages 141-161

   7. Treatment of Early Favorable Hodgkin Lymphoma

      • Elly Lugtenburg, Anton Hagenbeek

      Pages 163-181

   8. Treatment of Early Unfavorable HL

      • John M. M. Raemaekers, Andreas Engert

      Pages 183-190

   9. Treatment of Advanced Stage Hodgkin Lymphoma

      • Peter Borchmann, Volker Diehl

      Pages 191-202

   10. Relapsed and Refractory Hodgkin Lymphoma

       • Andreas Josting, Philip J. Biermann

       Pages 203-209

   11. Pediatric Hodgkin Lymphoma

       • Georgina Hall, Cindy Schwartz, Stephen Daw, Louis S. Constine

       Pages 211-225

4. Special Clinical Situations

   1. Front Matter

      Pages 227-227

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   2. Lymphocyte-Predominant Hodgkin Lymphoma

      • Andreas Engert, Anas Younes

      Pages 229-239

   3. The Management of Hodgkin Lymphoma During Pregnancy

      • Veronika Bachanova, Joseph M. Connors

      Pages 241-248

This book provides a well-illustrated, comprehensive, and up-to-date account of Hodgkin lymphoma. Epidemiology, pathogenesis, and the role of the microenvironment are examined in detail. The initial clinical evaluation and use of staging systems are fully discussed, and prognostic factors are carefully considered. The various treatment options for first-line and relapsed Hodgkin lymphoma are presented, including the newly available treatments for recurrent disease and the management required in special clinical circumstances. Given the very high cure rates and the young age of many patients, there is an increasing need to develop better individually tailored treatment strategies that will help to avoid both early and late side-effects of treatment. Such strategies receive due attention, and clear guidance is provided on the handling of Hodgkin survivors. This book will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.

• Diagnostic Procedures
• Etiology
• Hodgkin Lymphoma
• Late Effects and Survivorship
• Treatment of Firstline and Relapsed Hodgkin Lymphoma

• Klinik I für Innere Medizin, Universität Köln, Köln, Germany

  Andreas Engert

• Dept. Medicine, Stanford University, Stanford, USA

  Sandra J. Horning

Andreas Engert M.D. is Professor for Internal Medicine, Hematology and Oncology. He received his medical degree at the University of Hannover and had his medical training at the University of Hannover and the University Hospital of Cologne. Between 1988 and 1990 he worked at the Imperial Cancer Research Fund in London on new immunotherapeutic approaches for cancer. After returning to Cologne, he and his group focused on developing antibody-based immunotherapy for patients with malignant lymphoma resulting in a number of experimental phase I/II clinical trials. He finished his postdoctoral lecture qualification in 1995, was appointed consultant and became head of staff 1996. He was appointed coordinating editor of the Cochrane Hematological Malignancies Group (CHMG) and vice director of the Department for Hematology and Oncology in 2000. After Serving as Secretary of the German Hodgkin Study Group (GHSG) since 1999, Prof. Engert was elected GHSG chairman in 2007. For his scientific work, he has received numerous awards including the Ludwig-Heilmeyer-Medal, the Arthur-Pappenheim Award and the Research Award of the University of Cologne. The focus of his research for many years has been the development of targeted therapy to combat malignancy. Activities include constructs such as bispecific monoclonal antibodies, radioimmunoconjugates, humanized antibodies or immunoligands for diseases such as neuroblastoma, chronic lymphocytic, acute leukemias and malignant lymphoma. Prof. Engert treats patients with all malignancies and consults for lymphoma patients. In addition he is active in the field of evidence-based medicine as editor of the Cochrane Review Group for Hematological Malignancies (CHMG). The clinical focus of his work is the German Hodgkin Study Group (GHSG) with all of its different facets including planning and conducting clinical trials of all phases. The GHSG has conducted more than 20 randomized studies with more than 20.000 patients overall registered and is actively involved in a number of early clinical trials evaluating new drugs for patients with Hodgkin Lymphoma.

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